Difference between revisions of "Carney complex"

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The '''Carney complex''', also known as '''NAME syndrome''' and '''LAMB syndrome''', is a bunch of things that occur together due to some genetic problem.<ref>{{Ref WMSP|135}}</ref> It should not be confused with the [[Carney triad]].
The '''Carney complex''', also known as '''Carney syndrome''', '''NAME syndrome''' and '''LAMB syndrome''', is a bunch of things that occur together due to some genetic problem.<ref name=Ref_WMSP135>{{Ref WMSP|135}}</ref> It should not be confused with the [[Carney triad]].


NAME and LAMB are acronyms.
NAME and LAMB are acronyms that were proposed later.<ref name=emed1097150o>URL: [http://emedicine.medscape.com/article/1097150-overview http://emedicine.medscape.com/article/1097150-overview]. Accessed on: 25 May 2011.</ref>


==NAME==
In addition to the elements in ''NAME'' and ''LAMB'', it includes:
*[[Pituitary adenoma]].<ref name=Ref_PCPBoD8_554>{{Ref PCPBoD8|554}}</ref>
*[[Psammomatous melanotic schwannoma]].<ref name=emed1097150o>URL: [http://emedicine.medscape.com/article/1097150-overview http://emedicine.medscape.com/article/1097150-overview]. Accessed on: 25 May 2011.</ref>
 
==Types==
Two types exist:
*Carney complex type 1.<ref name=omim160980>{{OMIM|160980}}</ref>
**PRKAR1A gene.
*Carney complex type 2.<ref name=omim605244>{{OMIM|605244}}</ref>
**CNC gene.
 
==Acronyms==
===NAME===
NAME:
NAME:
*Nevi.
*[[Nevi]].
*[[Atrial myxoma]].  
*[[Atrial myxoma]].  
*Myxoid neurofibroma.
*Myxoid [[neurofibroma]].
*Ephelides (freckles<ref>URL: [http://emedicine.medscape.com/article/1119293-overview http://emedicine.medscape.com/article/1119293-overview]. Accessed on: 7 January 2011.</ref>).
*Ephelides (freckles<ref>URL: [http://emedicine.medscape.com/article/1119293-overview http://emedicine.medscape.com/article/1119293-overview]. Accessed on: 7 January 2011.</ref>).
**Pronounced ''e-FEE-le-DEEs''.<ref>URL: [http://www.merriam-webster.com/medlineplus/ephelides http://www.merriam-webster.com/medlineplus/ephelides]. Accessed on: 8 February 2012.</ref>


==LAMB==
===LAMB===
LAMB:  
LAMB:  
*Lentigines.  
*Lentigines.  
*Atrial myxomas.
**Focal melanocyte hyperplasia.
*[[Atrial myxoma]]s.
*Mucocutaneous myxomas.  
*Mucocutaneous myxomas.  
*Blue nevi.
*[[Blue nevi]].
 
Notes:
*Large calcifying [[sertoli cell tumours]] are also described in association ''Carney complex''.<ref name=pmid22732638>{{Cite journal  | last1 = Gourgari | first1 = E. | last2 = Saloustros | first2 = E. | last3 = Stratakis | first3 = CA. | title = Large-cell calcifying Sertoli cell tumors of the testes in pediatrics. | journal = Curr Opin Pediatr | volume = 24 | issue = 4 | pages = 518-22 | month = Aug | year = 2012 | doi = 10.1097/MOP.0b013e328355a279 | PMID = 22732638 }}</ref>
 
==See also==
*[[Peutz-Jeghers syndrome]].
*[[Carney triad]].
*[[Carney-Stratakis syndrome]].
*[[Myxoid lesions]].


==References==
==References==
{{Reflist|1}}
{{Reflist|2}}


[[Category:Syndromes]]
[[Category:Syndromes]]

Latest revision as of 04:05, 15 March 2016

The Carney complex, also known as Carney syndrome, NAME syndrome and LAMB syndrome, is a bunch of things that occur together due to some genetic problem.[1] It should not be confused with the Carney triad.

NAME and LAMB are acronyms that were proposed later.[2]

In addition to the elements in NAME and LAMB, it includes:

Types

Two types exist:

  • Carney complex type 1.[4]
    • PRKAR1A gene.
  • Carney complex type 2.[5]
    • CNC gene.

Acronyms

NAME

NAME:

LAMB

LAMB:

Notes:

See also

References

  1. Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 135. ISBN 978-0781765275.
  2. 2.0 2.1 URL: http://emedicine.medscape.com/article/1097150-overview. Accessed on: 25 May 2011.
  3. Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 554. ISBN 978-1416054542.
  4. Online 'Mendelian Inheritance in Man' (OMIM) 160980
  5. Online 'Mendelian Inheritance in Man' (OMIM) 605244
  6. URL: http://emedicine.medscape.com/article/1119293-overview. Accessed on: 7 January 2011.
  7. URL: http://www.merriam-webster.com/medlineplus/ephelides. Accessed on: 8 February 2012.
  8. Gourgari, E.; Saloustros, E.; Stratakis, CA. (Aug 2012). "Large-cell calcifying Sertoli cell tumors of the testes in pediatrics.". Curr Opin Pediatr 24 (4): 518-22. doi:10.1097/MOP.0b013e328355a279. PMID 22732638.