Cardiac arrhythmias

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Cardiac arrhythmias, especially ventricular ones, are a mechanism associated with sudden natural death.






Features - associated with ventricular fibrillation:[3]

  • Myofiberbreak-up (MFB) - key feature.
    • Fractures of the myofibres perpendicular to the long axis.
    • Associated with square nuclei.


  • In cases with malignant arrhythmias, as shown by cardiac monitor at the time of death, MFB is seen in multiple sections.[3]
  • MFB may be seen in noncardiac deaths.[3]



  1. Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 293. ISBN 978-1416054542.
  2. Prisant LM (April 2005). "Hypertensive heart disease". J Clin Hypertens (Greenwich) 7 (4): 231–8. PMID 15860963.
  3. 3.0 3.1 3.2 Baroldi, G.; Silver, MD.; Parolini, M.; Pomara, C.; Turillazzi, E.; Fineschi, V. (Apr 2005). "Myofiberbreak-up: a marker of ventricular fibrillation in sudden cardiac death.". Int J Cardiol 100 (3): 435-41. doi:10.1016/j.ijcard.2004.10.007. PMID 15837088.