Carcinoembryonic antigen

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Carcinoembryonic antigen, abbreviated CEA, is set of glycoproteins present during fetal development and associated with the gastrointestinal tract.

CEA immunostaining in C-cell hyperplasia. (WC)

In pathology, they are associated with gastrointestinal tract tumours; however, may be seen in other tumours.

Monoclonal & polyclonal

  • Several different types of CEA antibodies are available.

Broadly speaking they are divided into:

  • CEA-p = polyclonal CEA antibody.
  • CEA-m = monocloncal CEA antibody.

The staining is dependent on the specific antibody,[1] as is generally true.

Positive

See also

References

  1. Sheahan, K.; O'Brien, MJ.; Burke, B.; Dervan, PA.; O'Keane, JC.; Gottlieb, LS.; Zamcheck, N. (Aug 1990). "Differential reactivities of carcinoembryonic antigen (CEA) and CEA-related monoclonal and polyclonal antibodies in common epithelial malignancies.". Am J Clin Pathol 94 (2): 157-64. PMID 1695478.