Difference between revisions of "Carcinoembryonic antigen"

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[[Image:C-cell hyperplasia in MEN 2 - CEA -- very high mag.jpg|thumb|right|CEA immunostaining in C-cell hyperplasia. (WC)]]
[[Image:C-cell hyperplasia in MEN 2 - CEA -- very high mag.jpg|thumb|right|CEA immunostaining in [[C-cell hyperplasia]]. (WC)]]
'''Carcinoembryonic antigen''', abbreviated '''CEA''', is set of glycoproteins present during fetal development and associated with the gastrointestinal tract.   
'''Carcinoembryonic antigen''', abbreviated '''CEA''', is set of glycoproteins present during fetal development and associated with the gastrointestinal tract.   


In [[pathology]], they are associated with gastrointestinal tract tumours; however, may be seen in other tumours.
In [[pathology]], they are associated with gastrointestinal tract tumours; however, may be seen in other tumours.
==Monoclonal & polyclonal==
*Several different types of CEA antibodies are available.
Broadly speaking they are divided into:
*CEA-p = polyclonal CEA antibody.
*CEA-m = monocloncal CEA antibody.
The staining is dependent on the specific antibody,<ref name=pmid1695478>{{Cite journal  | last1 = Sheahan | first1 = K. | last2 = O'Brien | first2 = MJ. | last3 = Burke | first3 = B. | last4 = Dervan | first4 = PA. | last5 = O'Keane | first5 = JC. | last6 = Gottlieb | first6 = LS. | last7 = Zamcheck | first7 = N. | title = Differential reactivities of carcinoembryonic antigen (CEA) and CEA-related monoclonal and polyclonal antibodies in common epithelial malignancies. | journal = Am J Clin Pathol | volume = 94 | issue = 2 | pages = 157-64 | month = Aug | year = 1990 | doi =  | PMID = 1695478 }}</ref> as is generally true.


==Positive==
==Positive==
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*[[Medullary thyroid carcinoma]].
*[[Medullary thyroid carcinoma]].
*Eccrine glands of the [[skin]].
*Eccrine glands of the [[skin]].
*[[Endocervical adenocarcinoma]] - CEA-m (25 +ve of 26 cases<ref>{{Cite journal  | last1 = McCluggage | first1 = WG. | last2 = Sumathi | first2 = VP. | last3 = McBride | first3 = HA. | last4 = Patterson | first4 = A. | title = A panel of immunohistochemical stains, including carcinoembryonic antigen, vimentin, and estrogen receptor, aids the distinction between primary endometrial and endocervical adenocarcinomas. | journal = Int J Gynecol Pathol | volume = 21 | issue = 1 | pages = 11-5 | month = Jan | year = 2002 | doi =  | PMID = 11781517 }}</ref>).


==See also==
==See also==
*[[Immunohistochemistry]].
*[[Immunohistochemistry]].
==References==
{{Reflist|1}}


[[Category:Immunohistochemistry]]
[[Category:Immunohistochemistry]]

Latest revision as of 12:18, 5 August 2016

CEA immunostaining in C-cell hyperplasia. (WC)

Carcinoembryonic antigen, abbreviated CEA, is set of glycoproteins present during fetal development and associated with the gastrointestinal tract.

In pathology, they are associated with gastrointestinal tract tumours; however, may be seen in other tumours.

Monoclonal & polyclonal

  • Several different types of CEA antibodies are available.

Broadly speaking they are divided into:

  • CEA-p = polyclonal CEA antibody.
  • CEA-m = monocloncal CEA antibody.

The staining is dependent on the specific antibody,[1] as is generally true.

Positive

See also

References

  1. Sheahan, K.; O'Brien, MJ.; Burke, B.; Dervan, PA.; O'Keane, JC.; Gottlieb, LS.; Zamcheck, N. (Aug 1990). "Differential reactivities of carcinoembryonic antigen (CEA) and CEA-related monoclonal and polyclonal antibodies in common epithelial malignancies.". Am J Clin Pathol 94 (2): 157-64. PMID 1695478.
  2. McCluggage, WG.; Sumathi, VP.; McBride, HA.; Patterson, A. (Jan 2002). "A panel of immunohistochemical stains, including carcinoembryonic antigen, vimentin, and estrogen receptor, aids the distinction between primary endometrial and endocervical adenocarcinomas.". Int J Gynecol Pathol 21 (1): 11-5. PMID 11781517.