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Difference between revisions of "Carcinoembryonic antigen"
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[[Image:C-cell hyperplasia in MEN 2 - CEA -- very high mag.jpg|thumb|right|CEA immunostaining in C-cell hyperplasia. (WC)]] | [[Image:C-cell hyperplasia in MEN 2 - CEA -- very high mag.jpg|thumb|right|CEA immunostaining in [[C-cell hyperplasia]]. (WC)]] | ||
'''Carcinoembryonic antigen''', abbreviated '''CEA''', is set of glycoproteins present during fetal development and associated with the gastrointestinal tract. | '''Carcinoembryonic antigen''', abbreviated '''CEA''', is set of glycoproteins present during fetal development and associated with the gastrointestinal tract. | ||
In [[pathology]], they are associated with gastrointestinal tract tumours; however, may be seen in other tumours. | In [[pathology]], they are associated with gastrointestinal tract tumours; however, may be seen in other tumours. | ||
==Monoclonal & polyclonal== | |||
*Several different types of CEA antibodies are available. | |||
Broadly speaking they are divided into: | |||
*CEA-p = polyclonal CEA antibody. | |||
*CEA-m = monocloncal CEA antibody. | |||
The staining is dependent on the specific antibody,<ref name=pmid1695478>{{Cite journal | last1 = Sheahan | first1 = K. | last2 = O'Brien | first2 = MJ. | last3 = Burke | first3 = B. | last4 = Dervan | first4 = PA. | last5 = O'Keane | first5 = JC. | last6 = Gottlieb | first6 = LS. | last7 = Zamcheck | first7 = N. | title = Differential reactivities of carcinoembryonic antigen (CEA) and CEA-related monoclonal and polyclonal antibodies in common epithelial malignancies. | journal = Am J Clin Pathol | volume = 94 | issue = 2 | pages = 157-64 | month = Aug | year = 1990 | doi = | PMID = 1695478 }}</ref> as is generally true. | |||
==Positive== | ==Positive== | ||
*[[C-cell hyperplasia]]. | *[[C-cell hyperplasia]]. | ||
*[[Medullary thyroid carcinoma]]. | *[[Medullary thyroid carcinoma]]. | ||
*Eccrine glands of the [[skin]]. | *Eccrine glands of the [[skin]]. | ||
*[[Endocervical adenocarcinoma]] - CEA-m (25 +ve of 26 cases<ref>{{Cite journal | last1 = McCluggage | first1 = WG. | last2 = Sumathi | first2 = VP. | last3 = McBride | first3 = HA. | last4 = Patterson | first4 = A. | title = A panel of immunohistochemical stains, including carcinoembryonic antigen, vimentin, and estrogen receptor, aids the distinction between primary endometrial and endocervical adenocarcinomas. | journal = Int J Gynecol Pathol | volume = 21 | issue = 1 | pages = 11-5 | month = Jan | year = 2002 | doi = | PMID = 11781517 }}</ref>). | |||
==See also== | ==See also== | ||
*[[Immunohistochemistry]]. | *[[Immunohistochemistry]]. | ||
==References== | |||
{{Reflist|1}} | |||
[[Category:Immunohistochemistry]] | [[Category:Immunohistochemistry]] | ||