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Difference between revisions of "Canalicular adenoma"
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Canalicular_adenoma_--_high_mag.jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = Canalicular adenoma. [[H&E stain]]. (WC) | ||
| Synonyms = | | Synonyms = | ||
| Micro = | | Micro = cords of tumour ("canals") with beading (characteristic), cystic spaces/tubules, | ||
intraluminal squamous balls (common) | |||
| Subtypes = | | Subtypes = | ||
| LMDDx = | | LMDDx = | ||
| Line 16: | Line 17: | ||
| Grossing = | | Grossing = | ||
| Staging = | | Staging = | ||
| Site = [[salivary gland]] - usually upper lip | | Site = [[salivary gland]] - usually upper lip or buccal mucosa | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
| Line 49: | Line 50: | ||
==Microscopic== | ==Microscopic== | ||
Features: | Features:<ref name=pmid25141970/> | ||
* | *Cords of tumour ("canals") with beading - characteristic. | ||
* | *Cystic spaces/tubules. | ||
*Intraluminal squamous balls - common (~60% of cases). | |||
*Myxoid/bluish stroma. | |||
DDx: | DDx: | ||
| Line 57: | Line 60: | ||
===Images=== | ===Images=== | ||
*[http://www. | <gallery> | ||
*[http://www. | Image: Canalicular adenoma -- intermed mag.jpg | CA - intermed. mag. (WC) | ||
Image: Canalicular adenoma - alt -- intermed mag.jpg | CA - intermed. mag. (WC) | |||
Image: Canalicular adenoma -- high mag.jpg | CA - high mag. (WC) | |||
Image: Canalicular adenoma -- very high mag.jpg | CA - very high mag. (WC) | |||
Image: Canalicular adenoma - alt -- very high mag.jpg | CA - very high mag. (WC) | |||
</gallery> | |||
====www==== | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424207/figure/Fig2/ CA (nih.gov)].<ref name=pmid25141970/> | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424207/figure/Fig3/ CA with myxoid stroma (nih.gov)]. | |||
==IHC== | ==IHC== | ||
*[[ | Features:<ref name=pmid25141970/> | ||
** | *[[S-100]] +ve - diffuse and strong. | ||
*[[Pankeratin]] +ve - diffuse and strong. | |||
*GFAP +ve - luminal. | |||
*SOX10 +ve - nuclear. | |||
*p16 +ve - luminal squamous balls. | |||
*CK5/6 +ve - luminal squamous balls. | |||
*p63 -ve. | |||
**Nuclei negative, cytoplasm positive. | |||
**Positive in basal cell adenoma. | |||
==See also== | ==See also== | ||