Difference between revisions of "CD20"
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{{ Infobox immunostain | |||
| Name = {{PAGENAME}} | |||
| Image = Diffuse large B cell lymphoma (4) CD20.jpg | |||
| Width = | |||
| Caption = CD20 staining in a [[DLBCL]]. | |||
| Abbrev = | |||
| Synonyms = | |||
| Similar = CD79a, PAX5 | |||
| Clones = | |||
| Use = B-cell lymphomas | |||
| Subspecial = [[hematopathology]] | |||
| Pattern = membranous | |||
| Positive = most B-cell lymphomas | |||
| Negative = | |||
| Other = | |||
}} | |||
'''CD20''' is a B-cell marker. It is positive in most B-cell lymphoma. | '''CD20''' is a B-cell marker. It is positive in most B-cell lymphoma. | ||
==Lymphomas== | ==Lymphomas== | ||
===Negative B cell | ===Negative B cell lymphomas=== | ||
*[[Plasmablastic lymphoma]].<ref name=pmid15520070>{{Cite journal | last1 = Teruya-Feldstein | first1 = J. | last2 = Chiao | first2 = E. | last3 = Filippa | first3 = DA. | last4 = Lin | first4 = O. | last5 = Comenzo | first5 = R. | last6 = Coleman | first6 = M. | last7 = Portlock | first7 = C. | last8 = Noy | first8 = A. | title = CD20-negative large-cell lymphoma with plasmablastic features: a clinically heterogenous spectrum in both HIV-positive and -negative patients. | journal = Ann Oncol | volume = 15 | issue = 11 | pages = 1673-9 | month = Nov | year = 2004 | doi = 10.1093/annonc/mdh399 | PMID = 15520070 }}</ref> | *[[Plasmablastic lymphoma]].<ref name=pmid15520070>{{Cite journal | last1 = Teruya-Feldstein | first1 = J. | last2 = Chiao | first2 = E. | last3 = Filippa | first3 = DA. | last4 = Lin | first4 = O. | last5 = Comenzo | first5 = R. | last6 = Coleman | first6 = M. | last7 = Portlock | first7 = C. | last8 = Noy | first8 = A. | title = CD20-negative large-cell lymphoma with plasmablastic features: a clinically heterogenous spectrum in both HIV-positive and -negative patients. | journal = Ann Oncol | volume = 15 | issue = 11 | pages = 1673-9 | month = Nov | year = 2004 | doi = 10.1093/annonc/mdh399 | PMID = 15520070 }}</ref> | ||
*ALK+ large B-cell lymphoma. | *ALK+ large B-cell lymphoma. | ||
*Classical [[Hodgkin's lymphoma]]. | *Classical [[Hodgkin's lymphoma]]. | ||
===Abberant faint positive=== | |||
*T-cell lymphoma/leukemia - rare.<ref name=pmid27980301>{{Cite journal | last1 = Kawano | first1 = R. | last2 = Niino | first2 = D. | last3 = Ohshima | first3 = K. | title = Six Cases of CD20-Positive Adult T-Cell Leukemia. | journal = J Clin Exp Hematop | volume = 56 | issue = 2 | pages = 119-125 | month = | year = 2016 | doi = 10.3960/jslrt.56.119 | PMID = 27980301 }}</ref> | |||
==See also== | ==See also== | ||
Latest revision as of 03:51, 19 April 2019
| CD20 | |
|---|---|
| Immunostain in short | |
_CD20.jpg) CD20 staining in a DLBCL. | |
| Similar stains | CD79a, PAX5 |
| Use | B-cell lymphomas |
| Subspeciality | hematopathology |
| Normal staining pattern | membranous |
| Positive | most B-cell lymphomas |
CD20 is a B-cell marker. It is positive in most B-cell lymphoma.
Lymphomas
Negative B cell lymphomas
- Plasmablastic lymphoma.[1]
- ALK+ large B-cell lymphoma.
- Classical Hodgkin's lymphoma.
Abberant faint positive
- T-cell lymphoma/leukemia - rare.[2]
See also
References
- ↑ Teruya-Feldstein, J.; Chiao, E.; Filippa, DA.; Lin, O.; Comenzo, R.; Coleman, M.; Portlock, C.; Noy, A. (Nov 2004). "CD20-negative large-cell lymphoma with plasmablastic features: a clinically heterogenous spectrum in both HIV-positive and -negative patients.". Ann Oncol 15 (11): 1673-9. doi:10.1093/annonc/mdh399. PMID 15520070.
- ↑ Kawano, R.; Niino, D.; Ohshima, K. (2016). "Six Cases of CD20-Positive Adult T-Cell Leukemia.". J Clin Exp Hematop 56 (2): 119-125. doi:10.3960/jslrt.56.119. PMID 27980301.