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Difference between revisions of "Breast pathology"
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→Apocrine metaplasia: more
m (→Microscopic) |
(→Apocrine metaplasia: more) |
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*Benign/not significant. Can be considered to be pretty wallpaper in the house of breast pathology. | *Benign/not significant. Can be considered to be pretty wallpaper in the house of breast pathology. | ||
===Etiology=== | ====Etiology==== | ||
*Increased number of mitochondria. | *Increased number of mitochondria. | ||
**In other body sites this has different names, e.g. ''[[Hurthle cell change]]'' (thyroid), ''[[oncocytoma|oncocytic]] change'' (kidney - [[oncocytoma]], thyroid). | **In other body sites this has different names, e.g. ''[[Hurthle cell change]]'' (thyroid), ''[[oncocytoma|oncocytic]] change'' (kidney - [[oncocytoma]], thyroid). | ||
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===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Eosinophilic cytoplasm. | *Eosinophilic cytoplasm - '''key feature'''. | ||
*Apocrine snouts. | |||
**Small globules at the apical aspect of the cell (composed of cytoplasm and plasma membrane). | |||
Note: | Note: | ||
*Apocrine changes, i.e. cytoplasmic eosinophilia, can appear in malignant tumours; eosinophilia doesn't make | *Apocrine changes, i.e. cytoplasmic eosinophilia, can appear in malignant tumours; eosinophilia doesn't make something benign. | ||
Image: | |||
*[http://commons.wikimedia.org/wiki/File:Fibrocystic_change_-_very_high_mag.jpg FCC with apocrine metaplasia (right bottom of image) - high mag. (WC)]. | |||
==Fibrocystic change== | ==Fibrocystic change== | ||