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Difference between revisions of "Breast pathology"
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→Complex sclerosing lesion: more
(→Complex sclerosing lesion: more) |
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*[[AKA]] ''radial scar''. | *[[AKA]] ''radial scar''. | ||
===General=== | ===General=== | ||
*The term ''radial scar'' is a misnomer. It isn't a ''scar''. It isn't associated with prior trauma or surgery.<ref name=Ref_PBoD8_1072>{{Ref PBoD8|1072}}</ref> | |||
*May appear malignant on imaging.<ref name=pmid11167596>{{cite journal |author=Ung OA, Lee WB, Greenberg ML, Bilous M |title=Complex sclerosing lesion: the lesion is complex, the management is straightforward |journal=ANZ J Surg |volume=71 |issue=1 |pages=35–40 |year=2001 |month=January |pmid=11167596 |doi= |url=}}</ref> | *May appear malignant on imaging.<ref name=pmid11167596>{{cite journal |author=Ung OA, Lee WB, Greenberg ML, Bilous M |title=Complex sclerosing lesion: the lesion is complex, the management is straightforward |journal=ANZ J Surg |volume=71 |issue=1 |pages=35–40 |year=2001 |month=January |pmid=11167596 |doi= |url=}}</ref> | ||
*Associated with subsequent elevated risk of breast cancer.<ref>URL: [http://www.cancer.org/docroot/NWS/content/NWS_1_1x_Radial_Scars.asp http://www.cancer.org/docroot/NWS/content/NWS_1_1x_Radial_Scars.asp]. Accessed on: 4 May 2010.</ref> | *Associated with subsequent elevated risk of breast cancer.<ref>URL: [http://www.cancer.org/docroot/NWS/content/NWS_1_1x_Radial_Scars.asp http://www.cancer.org/docroot/NWS/content/NWS_1_1x_Radial_Scars.asp]. Accessed on: 4 May 2010.</ref> | ||
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**Scar like stroma with entrapped normal breast ducts and lobules. | **Scar like stroma with entrapped normal breast ducts and lobules. | ||
**Glands appear to enlarge with distance from center of lesion. | **Glands appear to enlarge with distance from center of lesion. | ||
Notes: | Notes: | ||
*Histomorphologic appearance may mimic a desmoplastic reaction of stroma - leading to a misdiagnosis of malignancy. | *Histomorphologic appearance may mimic a desmoplastic reaction of stroma - leading to a misdiagnosis of malignancy. | ||
*"[[Hyaline]] - pink stuff on H&E - is the key."<ref>RS. May 2010.</ref> | *"[[Hyaline]] - pink stuff on H&E - is the key."<ref>RS. May 2010.</ref> | ||
DDx: | |||
*[[Invasive ductal carcinoma]] - should be considered if the lesion is asymmetrical ''or'' glands are dilated centrally. | |||
Image: | |||
*[http://www.breastpathology.info/Images/Benign/Radial_scar/rs3a_700.jpg Radial scar (breastpathology.info)]. | |||
===IHC== | |||
Features: | |||
*p63 +ve. | |||
*Calponin +ve. | |||
=Stromal lesions= | =Stromal lesions= | ||