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Difference between revisions of "Breast pathology"
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==Columnar cell change== | ==Columnar cell change== | ||
=== | ===Importance=== | ||
*Columnar cell change is associated with (benign) calcification - '''key point'''. | |||
===Microscopic=== | |||
Features: | |||
*Secretory cells (line gland lumen) have columnar morphology. | *Secretory cells (line gland lumen) have columnar morphology. | ||
*May have "apical snouts". | *May have "apical snouts". | ||
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*Flat epithelial atypia (>2 cell layers).{{Fact}} | *Flat epithelial atypia (>2 cell layers).{{Fact}} | ||
=== | ==Sclerosing adenosis== | ||
* | ===General=== | ||
*Can be scary... can look like [[ductal carcinoma]]. | |||
*Derived from ''sclerosing''<ref>URL: [http://dictionary.reference.com/browse/sclerosis http://dictionary.reference.com/browse/sclerosis]. Accessed on: 16 March 2011.</ref> (hardening) and ''adenosis'' (glandular enlargement) | |||
**Think ''scaring'' + ''lotsa glands'' and you're pretty close. | |||
===Microscopic=== | |||
Features: | |||
*Acini are smaller than usual and there are more of them. | |||
*Fibrosis (scleroses) - pink on H&E surrounds the acini. | |||
**Can mimic a [[dysmoplastic reaction]]. | |||
Notes: | |||
*The acini should be: | |||
**In lobular arrangements, i.e. in groups. | |||
**Round. | |||
**Have two cell layers - like good breast glands do. | |||
=Lesions with increased risk of malignancy= | =Lesions with increased risk of malignancy= | ||
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*[[ADH]]. | *[[ADH]]. | ||
*Low grade [[DCIS]]. | *Low grade [[DCIS]]. | ||
==Complex sclerosing lesion== | ==Complex sclerosing lesion== | ||