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Difference between revisions of "Breast pathology"
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→Flat epithelial atypia
(→Stromal lesions of the breast: tweak, subdivide) |
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==Flat epithelial atypia== | ==Flat epithelial atypia== | ||
=== | ===General=== | ||
*Associated with | Epidemiology: | ||
*Associated with ADH & DCIS; may represent a non-obligate precursor lesion of ADH & DCIS.<ref name=pmid18384213>{{Cite journal | last1 = Lerwill | first1 = MF. | title = Flat epithelial atypia of the breast. | journal = Arch Pathol Lab Med | volume = 132 | issue = 4 | pages = 615-21 | month = Apr | year = 2008 | doi = 10.1043/1543-2165(2008)132[615:FEAOTB]2.0.CO;2 | PMID = 18384213 }}</ref> | |||
*Low risk of progression to invasive malignancy.<ref name=pmid12927037>{{Cite journal | last1 = Schnitt | first1 = SJ. | title = The diagnosis and management of pre-invasive breast disease: flat epithelial atypia--classification, pathologic features and clinical significance. | journal = Breast Cancer Res | volume = 5 | issue = 5 | pages = 263-8 | month = | year = 2003 | doi = 10.1186/bcr625 | PMID = 12927037 }}</ref> | |||
===Microscopic=== | ===Microscopic=== | ||
Features: | |||
*"Flat" ~ three cells thick. (???) | |||
*Hypercellular gland -- several layers. | *Hypercellular gland -- several layers. | ||
*Columnar cell morphology. | *Columnar cell morphology. | ||
*+/-Apical snouts. | *+/-Apical snouts. | ||
DDx: | |||
*Columnar cell change. | *[[Columnar cell change]]. | ||
*[[ADH]]. | |||
*Low grade [[DCIS]]. | |||
==Sclerosing adenosis== | ==Sclerosing adenosis== | ||