|
|
Line 481: |
Line 481: |
|
| |
|
| ==Fibroadenoma== | | ==Fibroadenoma== |
| ===General===
| | {{Main|Fibroadenoma}} |
| *Very common benign finding.
| |
| *The pathology is in the stroma; so, the lesion is really a misnomer by the naming rules.
| |
| **It ought to be called ''adenofibroma'' (as a few occasionally do<ref name=pmid15797289>{{Cite journal | last1 = Guinebretière | first1 = JM. | last2 = Menet | first2 = E. | last3 = Tardivon | first3 = A. | last4 = Cherel | first4 = P. | last5 = Vanel | first5 = D. | title = Normal and pathological breast, the histological basis. | journal = Eur J Radiol | volume = 54 | issue = 1 | pages = 6-14 | month = Apr | year = 2005 | doi = 10.1016/j.ejrad.2004.11.020 | PMID = 15797289 }}</ref>), as the glandular component is benign and the stromal component lesional; there is [[no truth in names]] in pathology.
| |
| | |
| Management:
| |
| *Local excision -- without a large margin.
| |
| | |
| ===Gross===
| |
| Features:<ref>{{Ref PCPBoD8|550}}</ref>
| |
| *Well-circumscribed.
| |
| *Rubbery - '''classic descriptor'''.
| |
| *Tan/white.
| |
| *+/-Lobulated appearance.
| |
| *+/-Slit-like spaces - short.
| |
| *+/-Calcification.
| |
| | |
| Images:
| |
| *[http://webpathology.com/image.asp?n=2&Case=276 Fibroadenoma - slit-like spaces (webpathology.com)].
| |
| *[http://webpathology.com/image.asp?case=276&n=3 Fibroadenoma - lobulated appearance (webpathology.com)].
| |
| *[http://www.surgical-tutor.org.uk/default-home.htm?tutorials/fibroadenoma.htm~right Fibroadenoma (surgical-tutor.org)].
| |
| | |
| ===Microscopic===
| |
| Features:<ref name=Ref_BP110>{{Ref BP|110}}</ref>
| |
| *Abundant (intralobular) stroma - most '''key feature'''.
| |
| **Stroma is usually:
| |
| ***White/pale, i.e. [[myxoid stroma|myxoid]], on H&E (normal stroma is pink).
| |
| ****May be hyalinized (dark pink) if infarcted.
| |
| ***Paucicellular - typical.
| |
| *Compression of glandular elements - very commonly seen.
| |
| **Glandular elements have at least two cell layers - epithelial and myoepithelial.
| |
| | |
| Notes:
| |
| #There is stuff about ''intracanalicular'' vs. ''pericanalicular''.<ref>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970216-9 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970216-9]. Accessed on: 16 March 2011.</ref> It is irrelevant; there is no prognostic difference between the two.
| |
| #Do '''not''' comment on the margin - it is irrelevant.
| |
| | |
| DDx:
| |
| *[[Phyllodes tumour]] - long slit-like spaces (seen grossly), stroma is more cellular.
| |
| **+/-Mitoses,
| |
| **+/-"Stromal overgrowth" = large area where there is a 'loss of glands'.
| |
| *Sarcoma.
| |
| *[[Pseudoangiomatous stromal hyperplasia]].
| |
| **Small capillary-like structures in the stroma.
| |
| ***Epithelial component often not compressed - as in fibroadenoma.
| |
| *[[Adenomyoepithelioma]] - for [[tubular adenoma of the breast]].
| |
| | |
| ====Images====
| |
| <gallery>
| |
| Image:Breast fibradenoma (1).jpg | Fibroadenoma. (WC/KGH)
| |
| Image:Breast_fibradenoma_(2).jpg | Fibroadenoma. (WC/KGH)
| |
| </gallery>
| |
| www:
| |
| *[http://radiographics.rsna.org/content/27/suppl_1/S101/F40.expansion.html Infarcted fibroadenoma (rsna.org)].<ref name=pmid18180221>{{Cite journal | last1 = Sabate | first1 = JM. | last2 = Clotet | first2 = M. | last3 = Torrubia | first3 = S. | last4 = Gomez | first4 = A. | last5 = Guerrero | first5 = R. | last6 = de las Heras | first6 = P. | last7 = Lerma | first7 = E. | title = Radiologic evaluation of breast disorders related to pregnancy and lactation. | journal = Radiographics | volume = 27 Suppl 1 | issue = | pages = S101-24 | month = Oct | year = 2007 | doi = 10.1148/rg.27si075505 | PMID = 18180221 }}</ref>
| |
| *[http://www.imagingpathways.health.wa.gov.au/includes/images/image/fibroadenoma_he.jpg Fibroadenoma (gov.au)].<ref>URL: [http://www.imagingpathways.health.wa.gov.au/includes/dipmenu/image/image.html http://www.imagingpathways.health.wa.gov.au/includes/dipmenu/image/image.html]. Accessed on: 15 February 2012.</ref>
| |
| | |
| ====Variants====
| |
| Four variants are described by the ''Washington Manual'':<ref name=Ref_WMSP262>{{Ref WMSP|262}}</ref>
| |
| #Juvenile.
| |
| #Complex.
| |
| #Myxoid.
| |
| #Cellular.
| |
| | |
| Considered a variant of fibroadenoma by many authorities:<ref name=Ref_BP116>{{Ref BP|116}}</ref>
| |
| *''[[Tubular adenoma of the breast]]''.
| |
| | |
| =====Juvenile fibroadenoma=====
| |
| *As the name suggests, is typically found in younger patients.
| |
| *Classic history: rapid growth.
| |
| | |
| Features (juvenile variant):<ref>URL: [http://www.breastpathology.info/fibro_variants.html#juvenile http://www.breastpathology.info/fibro_variants.html#juvenile]. Accessed on: 3 October 2011.</ref>
| |
| *Stromal and epithelial hyperplasia - '''key feature'''.
| |
| *+/-Tapering, thin micropapillae (''[[gynecomastoid hyperplasia]]'').<ref name=Ref_BP116>{{Ref BP|116}}</ref>
| |
| *Mitoses uncommon.
| |
| | |
| =====Myxoid fibroadenoma=====
| |
| *May be associated with ''[[Carney's complex]]''.
| |
| | |
| Features:
| |
| *[[Myxoid stroma]].
| |
| | |
| =====Cellular fibroadenoma=====
| |
| Features (cellular variant):
| |
| *Cellular.
| |
| *Mitoses.
| |
| | |
| =====Complex fibroadenoma=====
| |
| *Contain proliferative epithelium which outside and inside a fibroadenoma is associated with an increased risk of malignancy.
| |
| | |
| Features:<ref>URL: [http://www.breastpathology.info/fibro_variants.html#complex http://www.breastpathology.info/fibro_variants.html#complex]. Accessed on: 3 October 2011.</ref>
| |
| # [[Apocrine metaplasia]].
| |
| # Cysts > 3 mm.
| |
| # Calcification.
| |
| # [[Sclerosing adenosis]].
| |
| | |
| Memory devices:
| |
| *''FACS'': complex '''f'''ibroadenoma, '''a'''pocrine metaplasia, '''c'''alcs & '''c'''ysts, '''s'''clerosing adenosis.
| |
| *''CAMS'': '''c'''alcs, '''a'''pocrine metaplasia, '''m'''icrocysts, '''s'''clerosing adenosis.
| |
| | |
| =====Tubular adenoma of the breast=====
| |
| *Considered by many a variant of ''fibroadenoma''.
| |
| **[[IHC]] features of ''tubular adenoma of the breast'' and ''fibroadenoma'' are similar.<ref>{{Cite journal | last1 = Maiorano | first1 = E. | last2 = Albrizio | first2 = M. | title = Tubular adenoma of the breast: an immunohistochemical study of ten cases. | journal = Pathol Res Pract | volume = 191 | issue = 12 | pages = 1222-30 | month = Dec | year = 1995 | doi = | PMID = 8927570 }}</ref>
| |
| | |
| Features:<ref name=Ref_BP116>{{Ref BP|116}}</ref>
| |
| *Fibromyxoid stroma (like in a fibroadenoma).
| |
| *Small round glands.
| |
| | |
| Images:
| |
| *[http://www.webpathology.com/image.asp?case=277&n=1 Tubular adenoma of the breast (webpathology.com)].
| |
| <gallery>
| |
| Image:Tubular_Adenoma_of_Breast_(myosin_immunostain)_(4351463966).jpg | TA of the breast - myosin IHC. (WC)
| |
| </gallery>
| |
|
| |
|
| ==Phyllodes tumour== | | ==Phyllodes tumour== |