Difference between revisions of "Benign lymphoepithelial lesion"
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'''Benign lymphoepithelial lesion''', also known as '''benign lymphoepithelial cyst''', is a rare benign lesion of the [[head and neck pathology|head and neck]]. | |||
It should '''not''' be confused the ''[[lymphoepithelial lesion]]'' found in the GI tract. | |||
==General== | |||
*Usually parotid gland. | |||
*Associated with autoimmune disease, e.g. [[Sjoegren disease]], may not remain benign.<ref name=pmid12058269>{{Cite journal | last1 = Goto | first1 = TK. | last2 = Shimizu | first2 = M. | last3 = Kobayashi | first3 = I. | last4 = Chikui | first4 = T. | last5 = Kanda | first5 = S. | last6 = Toshitani | first6 = K. | last7 = Shiratsuchi | first7 = Y. | last8 = Yoshida | first8 = K. | title = Lymphoepithelial lesion of the parotid gland. | journal = Dentomaxillofac Radiol | volume = 31 | issue = 3 | pages = 198-203 | month = May | year = 2002 | doi = 10.1038/sj/dmfr/4600690 | PMID = 12058269 }}</ref> | |||
*May be seen in the context of [[HIV]].<ref>{{cite journal |authors=Sekikawa Y, Hongo I |title=HIV-associated benign lymphoepithelial cysts of the parotid glands confirmed by HIV-1 p24 antigen immunostaining |journal=BMJ Case Rep |volume=2017 |issue= |pages= |date=September 2017 |pmid=28963391 |pmc=5652621 |doi=10.1136/bcr-2017-221869 |url=}}</ref> | |||
==Microscopic== | |||
Features: | |||
*Lymphocytes. | |||
*Ductal epithelial cells.<ref name=pmid12761623>{{Cite journal | last1 = Metwaly | first1 = H. | last2 = Cheng | first2 = J. | last3 = Ida-Yonemochi | first3 = H. | last4 = Ohshiro | first4 = K. | last5 = Jen | first5 = KY. | last6 = Liu | first6 = AR. | last7 = Saku | first7 = T. | title = Vascular endothelial cell participation in formation of lymphoepithelial lesions (epi-myoepithelial islands) in lymphoepithelial sialadenitis (benign lymphoepithelial lesion). | journal = Virchows Arch | volume = 443 | issue = 1 | pages = 17-27 | month = Jul | year = 2003 | doi = 10.1007/s00428-003-0824-0 | PMID = 12761623 }}</ref> | |||
Note: | |||
*'''Must''' rule-out (MALT) [[MALT lymphoma|lymphoma]]. | |||
==IHC== | |||
*CD20, CD3 -- mixed population. | |||
*Kappa ~ lambda. | |||
==Sign out== | |||
<pre> | |||
Right Total Parotid Gland, Excision: | |||
- Lymphoepithelial lesion/cyst, benign. | |||
- Benign parotid gland. | |||
- Two lymph nodes, NEGATIVE for malignancy (0/2). | |||
</pre> | |||
===Micro=== | |||
The sections show a multiloculated cyst with thin walls containing bland lymphoid cells and unremarkable paucicellular fibrotic tissue. The lymphoid component has germinal centre formation. The cyst lining is predominantly a simple thin epithelium. Minimal cytoplasm is present in the cyst lining. Focally, the epithelium is multilayered; however, pseudo-bilayering is absent. No significant atypia is present. Proliferative activity is not apparent. | |||
==See also== | |||
*[[Head and neck pathology]]. | |||
*[[Lymphoepithelial lesion]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Head and neck pathology]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
Latest revision as of 21:18, 15 December 2021
Benign lymphoepithelial lesion, also known as benign lymphoepithelial cyst, is a rare benign lesion of the head and neck.
It should not be confused the lymphoepithelial lesion found in the GI tract.
General
- Usually parotid gland.
- Associated with autoimmune disease, e.g. Sjoegren disease, may not remain benign.[1]
- May be seen in the context of HIV.[2]
Microscopic
Features:
- Lymphocytes.
- Ductal epithelial cells.[3]
Note:
- Must rule-out (MALT) lymphoma.
IHC
- CD20, CD3 -- mixed population.
- Kappa ~ lambda.
Sign out
Right Total Parotid Gland, Excision:
- Lymphoepithelial lesion/cyst, benign.
- Benign parotid gland.
- Two lymph nodes, NEGATIVE for malignancy (0/2).
Micro
The sections show a multiloculated cyst with thin walls containing bland lymphoid cells and unremarkable paucicellular fibrotic tissue. The lymphoid component has germinal centre formation. The cyst lining is predominantly a simple thin epithelium. Minimal cytoplasm is present in the cyst lining. Focally, the epithelium is multilayered; however, pseudo-bilayering is absent. No significant atypia is present. Proliferative activity is not apparent.
See also
References
- ↑ Goto, TK.; Shimizu, M.; Kobayashi, I.; Chikui, T.; Kanda, S.; Toshitani, K.; Shiratsuchi, Y.; Yoshida, K. (May 2002). "Lymphoepithelial lesion of the parotid gland.". Dentomaxillofac Radiol 31 (3): 198-203. doi:10.1038/sj/dmfr/4600690. PMID 12058269.
- ↑ Sekikawa Y, Hongo I (September 2017). "HIV-associated benign lymphoepithelial cysts of the parotid glands confirmed by HIV-1 p24 antigen immunostaining". BMJ Case Rep 2017. doi:10.1136/bcr-2017-221869. PMC 5652621. PMID 28963391. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652621/.
- ↑ Metwaly, H.; Cheng, J.; Ida-Yonemochi, H.; Ohshiro, K.; Jen, KY.; Liu, AR.; Saku, T. (Jul 2003). "Vascular endothelial cell participation in formation of lymphoepithelial lesions (epi-myoepithelial islands) in lymphoepithelial sialadenitis (benign lymphoepithelial lesion).". Virchows Arch 443 (1): 17-27. doi:10.1007/s00428-003-0824-0. PMID 12761623.