Difference between revisions of "Ballooning degeneration"
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==General== | ==General== | ||
*A form of apoptosis.<ref name=pmid17355088>{{Cite journal | last1 = Yip | first1 = WW | last2 = Burt | first2 = AD | title = Alcoholic liver disease. | journal = Semin Diagn Pathol | volume = 23 | issue = 3-4 | pages = 149–60 | month = | year = 2006| doi = 10.1053/j.semdp.2006.11.002| pmid = 17355088 }}</ref> | *A form of [[apoptosis]].<ref name=pmid17355088>{{Cite journal | last1 = Yip | first1 = WW | last2 = Burt | first2 = AD | title = Alcoholic liver disease. | journal = Semin Diagn Pathol | volume = 23 | issue = 3-4 | pages = 149–60 | month = | year = 2006| doi = 10.1053/j.semdp.2006.11.002| pmid = 17355088 }}</ref> | ||
*Fatty change without ballooning degeneration is [[steatosis]]. | *Fatty change without ballooning degeneration is [[steatosis]]. | ||
*Typically seen in the context of [[obesity]] or [[alcohol]]. | *Typically seen in the context of [[obesity]] or [[alcohol]]. | ||
| Line 21: | Line 21: | ||
DDx: | DDx: | ||
*[[Feathery degeneration]] - has | *[[Feathery degeneration]] - has a similar morphology; however, noticeable (yellow) bile is present. | ||
===Images=== | ===Images=== | ||
Latest revision as of 23:05, 3 January 2016
Ballooning degeneration. H&E stain. (WC)
Ballooning degeneration is a histomorphologic change seen in liver pathology. It is indicative of steatohepatitis.[1]
General
- A form of apoptosis.[2]
- Fatty change without ballooning degeneration is steatosis.
- Typically seen in the context of obesity or alcohol.
Microscopic
Features:
- Central nucleus.
- "Fat cells" have peripheral nucleus.
- Cytoplasm cleared with "whisps" or cobbwebs.
- Large relative to normal hepatocyte.
- 2-3X normal size.[3]
Notes:
- The term is used only in conjunction with steatohepatitis.
- Feathery degeneration is the term used in the context of cholestasis.
- It is usually periportal.
DDx:
- Feathery degeneration - has a similar morphology; however, noticeable (yellow) bile is present.
Images
Ballooning degeneration. (WC/Nephron)
Ballooning degeneration. (WC/Nephron)
www:
See also
References
- ↑ Liangpunsakul, S; Chalasani, N (Dec 2003). "Treatment of Nonalcoholic Fatty Liver Disease.". Curr Treat Options Gastroenterol 6 (6): 455-463. PMID 14585234.
- ↑ Yip, WW; Burt, AD (2006). "Alcoholic liver disease.". Semin Diagn Pathol 23 (3-4): 149–60. doi:10.1053/j.semdp.2006.11.002. PMID 17355088.
- ↑ Guindi, M. 16 September 2009.