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Difference between revisions of "Atypical fibroxanthoma"
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Atypical fibroxanthoma (view source)
Revision as of 02:56, 22 December 2013
, 02:56, 22 December 2013no edit summary
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = | |||
| Width = | |||
| Caption = | |||
| Synonyms = | |||
| Micro = dermal lesion with marked nuclear atypia, mitoses, mulitnucleated cells, cell have foamy cytoplasm | |||
| Subtypes = | |||
| LMDDx = [[malignant melanoma]], [[pleomorphic undifferentiated sarcoma]], [[leiomyosarcoma]], sarcomatoid [[squamous carcinoma]] | |||
| Stains = | |||
| IHC = S-100 -ve, CK34betaE12 -ve, p63 -ve, desmin -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[skin]] - see [[skin tumours]], usu. head & neck | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = rapid growth, elderly | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = good | |||
| Other = | |||
| ClinDDx = malignant [[skin tumours]] | |||
| Tx = complete excision | |||
}} | |||
'''Atypical fibroxanthoma''', abbreviated '''AFX''', is poorly differentiated [[skin tumour]] with likeness to [[undifferentiated pleomorphic sarcoma]]. | '''Atypical fibroxanthoma''', abbreviated '''AFX''', is poorly differentiated [[skin tumour]] with likeness to [[undifferentiated pleomorphic sarcoma]]. | ||
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DDx: | DDx: | ||
*[[ | *[[Malignant melanoma]]. | ||
*[[Pleomorphic undifferentiated sarcoma]] (MFH) - deeper than the dermis. | *[[Pleomorphic undifferentiated sarcoma]] (MFH) - deeper than the dermis. | ||
*[[Leiomyosarcoma]]. | *[[Leiomyosarcoma]]. | ||
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Features:<ref name=Ref_Derm521>{{Ref Derm|521}}</ref> | Features:<ref name=Ref_Derm521>{{Ref Derm|521}}</ref> | ||
*S100 -ve (done to r/o melanoma). | *S100 -ve (done to r/o melanoma). | ||
* | *CK34betaE12 -ve. | ||
*p63 -ve (done to exclude SCC) | *p63 -ve (done to exclude [[squamous cell carcinoma of the skin|SCC]]). | ||
**Scant staining not considered +ve. | **Scant staining not considered +ve. | ||
*Desmin -ve (done to r/o leiomyosarcoma). | *Desmin -ve (done to r/o leiomyosarcoma). | ||