Difference between revisions of "Atrophic prostate carcinoma"
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# | '''Atrophic prostate carcinoma''' is a type of [[prostate cancer]] that typically co-exists with conventional (acinar) prostate carcinoma. As its name implies, it has atrophic changes and can mimic (benign) [[prostate with atrophic changes]]. | ||
==General== | |||
*Uncommon. | |||
Note: | |||
*An atrophic component in prostate cancer is common; one study identified it in ~15% of cases.<ref name=pmid9620026>{{Cite journal | last1 = Kaleem | first1 = Z. | last2 = Swanson | first2 = PE. | last3 = Vollmer | first3 = RT. | last4 = Humphrey | first4 = PA. | title = Prostatic adenocarcinoma with atrophic features: a study of 202 consecutive completely embedded radical prostatectomy specimens. | journal = Am J Clin Pathol | volume = 109 | issue = 6 | pages = 695-703 | month = Jun | year = 1998 | doi = | PMID = 9620026 }}</ref> | |||
==Microscopic== | |||
Features: | |||
*Scant cytoplasm. | |||
*Nuclear features of conventional prostate cancer (nucleoli, nuclear enlargement). | |||
*+/-Increased gland density. | |||
DDx: | |||
*[[Atrophy of the prostate]]. | |||
===Images=== | |||
*[http://www.nature.com/modpathol/journal/v17/n3/fig_tab/3800050f12.html#figure-title Atrophic carcinoma (nature.com)]. | |||
==IHC== | |||
*p63 -ve. | |||
**Rare p63 +ve prostate carcinoma is reported.<ref name=pmid23991727>{{Cite journal | last1 = Wu | first1 = A. | last2 = Kunju | first2 = LP. | title = Prostate cancer with aberrant diffuse p63 expression: report of a case and review of the literature and morphologic mimics. | journal = Arch Pathol Lab Med | volume = 137 | issue = 9 | pages = 1179-84 | month = Sep | year = 2013 | doi = 10.5858/arpa.2013-0254-CR | PMID = 23991727 }}</ref> | |||
==See also== | |||
*[[Prostate carcinoma]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Genitourinary pathology]] | |||
Latest revision as of 06:40, 17 November 2014
Atrophic prostate carcinoma is a type of prostate cancer that typically co-exists with conventional (acinar) prostate carcinoma. As its name implies, it has atrophic changes and can mimic (benign) prostate with atrophic changes.
General
- Uncommon.
Note:
- An atrophic component in prostate cancer is common; one study identified it in ~15% of cases.[1]
Microscopic
Features:
- Scant cytoplasm.
- Nuclear features of conventional prostate cancer (nucleoli, nuclear enlargement).
- +/-Increased gland density.
DDx:
Images
IHC
- p63 -ve.
- Rare p63 +ve prostate carcinoma is reported.[2]
See also
References
- ↑ Kaleem, Z.; Swanson, PE.; Vollmer, RT.; Humphrey, PA. (Jun 1998). "Prostatic adenocarcinoma with atrophic features: a study of 202 consecutive completely embedded radical prostatectomy specimens.". Am J Clin Pathol 109 (6): 695-703. PMID 9620026.
- ↑ Wu, A.; Kunju, LP. (Sep 2013). "Prostate cancer with aberrant diffuse p63 expression: report of a case and review of the literature and morphologic mimics.". Arch Pathol Lab Med 137 (9): 1179-84. doi:10.5858/arpa.2013-0254-CR. PMID 23991727.