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→Uncommon: + Diffuse hemispheric glioma, H3 G34-mutant
Jensflorian (talk | contribs) (Add Astrocytoma MYB/L) |
Jensflorian (talk | contribs) (→Uncommon: + Diffuse hemispheric glioma, H3 G34-mutant) |
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* Genetic studies indicate strong overlap with diffuse astrocytic gliomas, oligodendrogliomas and glioblastoma. | * Genetic studies indicate strong overlap with diffuse astrocytic gliomas, oligodendrogliomas and glioblastoma. | ||
==Diffuse midline glioma, H3 | ==Diffuse midline glioma, H3 K27-altered== | ||
* High-grade astrocytic neoplasm associated with midline structures (thalamus, brain stem, spinal cord). | * High-grade astrocytic neoplasm associated with midline structures (thalamus, brain stem, spinal cord). | ||
* Mostly in children and adolescents. | * Mostly in children and adolescents. | ||
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File:K27M mutant diffuse glioma of the midline.jpg|Nuclear [[H3F3A]] K27M immunostaining in a diffuse glioma of the midline. (WC/jensflorian) | File:K27M mutant diffuse glioma of the midline.jpg|Nuclear [[H3F3A]] K27M immunostaining in a diffuse glioma of the midline. (WC/jensflorian) | ||
</gallery> | </gallery> | ||
==Diffuse hemispheric glioma, H3 G34-mutant== | |||
* Infiltrative hemispheric glioma of young adults. | |||
* Glioblastoma-like appearance (CNS WHO grade 4 tumor). | |||
* Newly defined entity in WHO 2021 classification. | |||
* H3F3A missense mutation G34R or G34V. | |||
{{Main|Diffuse hemispheric glioma, H3 G34-mutant}} | |||
==Gliosarcoma== | ==Gliosarcoma== | ||