Difference between revisions of "Aspergillosis"

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#redirect [[Fungi#Aspergillosis]]
[[Image:Aspergillus - add - very high mag.jpg|thumb|right|Aspergillus with classic fruiting heads. [[H&E stain]].]]
'''Aspergillosis''' is a [[fungi|fungal infection]] due to ''Asperillus''.
 
==General==
*Due to ''Aspergillus''.
*Fungus.
*Associated with immunosuppression/immunodeficiency.
**Rarely in immune competent individuals.<ref name=pmid7844909>{{Cite journal  | last1 = Sugimura | first1 = S. | last2 = Yoshida | first2 = K. | last3 = Oba | first3 = H. | last4 = Hashiguchi | first4 = K. | last5 = Nakajima | first5 = M. | last6 = Moriya | first6 = O. | last7 = Okimoto | first7 = N. | last8 = Niki | first8 = Y. | last9 = Soejima | first9 = R. | title = [Two cases of invasive pulmonary aspergillosis in non-immunocompromised hosts]. | journal = Nihon Kyobu Shikkan Gakkai Zasshi | volume = 32 | issue = 10 | pages = 1032-7 | month = Oct | year = 1994 | doi =  | PMID = 7844909 }}
</ref>
 
==Microscopic==
Features:
*Hyphae that branching with 45 degrees angle - '''key feature'''.<ref name=Ref_APBR682>{{Ref APBR|682}}</ref>
**Uniform width - typically ~3-5 μm.
*Septated - often difficult to see.
*"Fruiting heads" when aerobic - uncommon.
**Spherical structures ~50 micrometres in diameter with radially arranged structures (like spokes of a wheel) +/- an empty centre in the plane of section.
 
DDx:
*[[Mucormycosis]] - irregular width.
*Scedosporium prolificans - in immunoincompetent individuals.<ref>URL: [http://path.upmc.edu/cases/case290.html http://path.upmc.edu/cases/case290.html]. Accessed on: 14 January 2012.</ref>
*[[Candida]].<ref name=pmid21482725>{{Cite journal  | last1 = Guarner | first1 = J. | last2 = Brandt | first2 = ME. | title = Histopathologic diagnosis of fungal infections in the 21st century. | journal = Clin Microbiol Rev | volume = 24 | issue = 2 | pages = 247-80 | month = Apr | year = 2011 | doi = 10.1128/CMR.00053-10 | PMID = 21482725 }}</ref>
 
====Images====
<gallery>
Image:Pulmonary_aspergillosis.jpg  | Aspergillus (WC)
Image:Pulmonary_aspergillosis_cytology.jpg | Aspergillus - [[cytology]]. (WC)
Image:Aspergillus_-_high_mag.jpg | Aspergillus with fruiting head - high mag. (WC)
Image:Aspergillus_-_add_-_very_high_mag.jpg | Aspergillus with fruiting head - very high mag. (WC)
File:Aspergillosis, angioinvasive, - GMS stain (5390967417).jpg | Angionvasive aspergillosis. (WC/Yale Rosen)
File:Aspergillosis, granulomatous (5390380567).jpg | Granulomatous reaction in aspergillosis - HE.(WC/Yale Rosen)
File:Aspergilloma (5390379559).jpg | Aspergilloma. (WC/Yale Rosen)
</gallery>
www:
*[http://www.ispub.com/journal/the-internet-journal-of-otorhinolaryngology/volume-6-number-1/maxillary-sinus-mycetoma-due-to-aspergillus-niger.article-g03.fs.jpg Aspergillosis - fruiting head (ispub.com)].<ref>URL: [http://www.ispub.com/journal/the-internet-journal-of-otorhinolaryngology/volume-6-number-1/maxillary-sinus-mycetoma-due-to-aspergillus-niger.html http://www.ispub.com/journal/the-internet-journal-of-otorhinolaryngology/volume-6-number-1/maxillary-sinus-mycetoma-due-to-aspergillus-niger.html]. Accessed on: 27 February 2012.</ref>
 
==Stains==
*[[PAS-D stain]] +ve.
 
==See also==
*[[Fungi]].
*[[Microorganisms]].
 
==References==
{{Reflist|1}}
 
[[Category:Diagnosis]]
[[Category:Microorganisms]]

Latest revision as of 20:53, 27 May 2016

Aspergillus with classic fruiting heads. H&E stain.

Aspergillosis is a fungal infection due to Asperillus.

General

  • Due to Aspergillus.
  • Fungus.
  • Associated with immunosuppression/immunodeficiency.
    • Rarely in immune competent individuals.[1]

Microscopic

Features:

  • Hyphae that branching with 45 degrees angle - key feature.[2]
    • Uniform width - typically ~3-5 μm.
  • Septated - often difficult to see.
  • "Fruiting heads" when aerobic - uncommon.
    • Spherical structures ~50 micrometres in diameter with radially arranged structures (like spokes of a wheel) +/- an empty centre in the plane of section.

DDx:

Images

  • Aspergillus (WC)

  • Aspergillus - cytology. (WC)

  • Aspergillus with fruiting head - high mag. (WC)

  • Aspergillus with fruiting head - very high mag. (WC)

  • Angionvasive aspergillosis. (WC/Yale Rosen)

  • Granulomatous reaction in aspergillosis - HE.(WC/Yale Rosen)

  • Aspergilloma. (WC/Yale Rosen)

www:

Stains

See also

References

  1. ↑ Sugimura, S.; Yoshida, K.; Oba, H.; Hashiguchi, K.; Nakajima, M.; Moriya, O.; Okimoto, N.; Niki, Y. et al. (Oct 1994). "[Two cases of invasive pulmonary aspergillosis in non-immunocompromised hosts].". Nihon Kyobu Shikkan Gakkai Zasshi 32 (10): 1032-7. PMID 7844909.
  2. ↑ Lefkowitch, Jay H. (2006). Anatomic Pathology Board Review (1st ed.). Saunders. pp. 682. ISBN 978-1416025887.
  3. ↑ URL: http://path.upmc.edu/cases/case290.html. Accessed on: 14 January 2012.
  4. ↑ Guarner, J.; Brandt, ME. (Apr 2011). "Histopathologic diagnosis of fungal infections in the 21st century.". Clin Microbiol Rev 24 (2): 247-80. doi:10.1128/CMR.00053-10. PMID 21482725.
  5. ↑ URL: http://www.ispub.com/journal/the-internet-journal-of-otorhinolaryngology/volume-6-number-1/maxillary-sinus-mycetoma-due-to-aspergillus-niger.html. Accessed on: 27 February 2012.
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