Difference between revisions of "Angiomyofibroblastoma"

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'''Angiomyofibroblastoma''' is rare uncommon [[soft tissue lesion]] of the [[vulva]].
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Angiomyofibroblastoma humpath 4.jpg
| Width      =
| Caption    = Angiomyofibroblastoma. [[H&E stain]].
| Synonyms  =
| Micro      = hypercellular zones and hypocellular edematous zones, small blood vessels (~20 micrometers) - no large blood vessels, [[myxoid stroma]], small stellate cell/spindle cells without significant nuclear atypia
| Subtypes  =
| LMDDx      = [[aggressive angiomyxoma]]
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      = well-circumscribed
| Grossing  =
| Site      = female pelvis ([[vulva]]), case reports of similar lesion in males
| Assdx      =
| Syndromes  =
| Clinicalhx = slow growing, usu. not painful
| Signs      =
| Symptoms  =
| Prevalence = very rare
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  =
| Other      =
| ClinDDx    = [[Bartholin cyst]], [[aggressive angiomyxoma]]
| Tx        =
}}
'''Angiomyofibroblastoma''', abbreviated '''AMF''',<ref name=pmid15782077>{{cite journal |author=Cao D, Srodon M, Montgomery EA, Kurman RJ |title=Lipomatous variant of angiomyofibroblastoma: report of two cases and review of the literature |journal=Int. J. Gynecol. Pathol. |volume=24 |issue=2 |pages=196–200 |year=2005 |month=April |pmid=15782077 |doi= |url=}}</ref> is rare uncommon [[soft tissue lesion]] of the [[vulva]].


==General==
==General==
*Uncommon.
*Uncommon.
*Similar lesions reported in males.<ref name=pmid24396463>{{Cite journal  | last1 = Ding | first1 = G. | last2 = Yu | first2 = Y. | last3 = Jin | first3 = M. | last4 = Xu | first4 = J. | last5 = Zhang | first5 = Z. | title = Angiomyofibroblastoma-like tumor of the scrotum: A case report and literature review. | journal = Oncol Lett | volume = 7 | issue = 2 | pages = 435-438 | month = Feb | year = 2014 | doi = 10.3892/ol.2013.1741 | PMID = 24396463 }}</ref><ref>{{Cite journal  | last1 = Butt | first1 = Z. | last2 = Slatnik | first2 = J. | last3 = Estey | first3 = EP. | title = Robotic assisted laparoscopic excision of a pelvic angiomyofibroblastoma-like tumor. | journal = Can J Urol | volume = 20 | issue = 6 | pages = 7067-9 | month = Dec | year = 2013 | doi =  | PMID = 24331351 }}</ref>
Clinical:<ref name=pmid24328028/>
*Slow growing.
*Uncommonly recur.
*Usually painless.


Clinical DDx:
Clinical DDx:
*[[Bartholin cyst]].
*[[Bartholin cyst]].
==Gross==
*[[Vulva|Vulvar lesion]].
*Well-circumscribed.<ref name=pmid24328028>{{Cite journal  | last1 = Seo | first1 = JW. | last2 = Lee | first2 = KA. | last3 = Yoon | first3 = NR. | last4 = Lee | first4 = JW. | last5 = Kim | first5 = BG. | last6 = Bae | first6 = DS. | title = Angiomyofibroblastoma of the vulva. | journal = Obstet Gynecol Sci | volume = 56 | issue = 5 | pages = 349-51 | month = Sep | year = 2013 | doi = 10.5468/ogs.2013.56.5.349 | PMID = 24328028 }}</ref>


==Microscopic==
==Microscopic==
Line 18: Line 59:


===Images===
===Images===
<gallery>
Image:Angiomyofibroblastoma humpath 1.jpg | AMF - low mag.
Image:Angiomyofibroblastoma humpath 2.jpg | AMF - intermed. mag.
Image:Angiomyofibroblastoma humpath 3.jpg | AMF - high mag.
Image:Angiomyofibroblastoma humpath 4.jpg | AMF - very high mag.
</gallery>
www:
www:
*[http://www.webpathology.com/image.asp?case=544&n=4 Angiomyofibroblastoma (webpathology.com)]
*[http://www.webpathology.com/image.asp?case=544&n=4 Angiomyofibroblastoma (webpathology.com)]
*[http://www.webpathology.com/image.asp?n=5&Case=544 Angiomyofibroblastoma - high mag. (webpathology.com)].
*[http://www.webpathology.com/image.asp?n=5&Case=544 Angiomyofibroblastoma - high mag. (webpathology.com)].
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881198/figure/f2-ol-07-02-0435/ Angiomyofibroblastoma-like tumour of scrotum (nih.gov)].<ref name=pmid24396463/>
==IHC==
*Desmin +ve.<ref name=pmid24328028/>
*Vimentin +ve.<ref name=pmid24328028/>
*SMA +ve.
*S-100 -ve.
*Actin -ve.
*CD34 -ve.


==See also==
==See also==
*[[Soft tissue lesions]].
*[[Soft tissue lesions]].
*[[Vulva]].
*[[Scrotum]].


==References==
==References==

Latest revision as of 07:56, 8 May 2014

Angiomyofibroblastoma, abbreviated AMF,[1] is rare uncommon soft tissue lesion of the vulva.

Angiomyofibroblastoma
Diagnosis in short

Angiomyofibroblastoma. H&E stain.
LM hypercellular zones and hypocellular edematous zones, small blood vessels (~20 micrometers) - no large blood vessels, myxoid stroma, small stellate cell/spindle cells without significant nuclear atypia
LM DDx aggressive angiomyxoma
Gross well-circumscribed
Site female pelvis (vulva), case reports of similar lesion in males
Clinical history slow growing, usu. not painful
Prevalence very rare
Clin. DDx Bartholin cyst, aggressive angiomyxoma

General

  • Uncommon.
  • Similar lesions reported in males.[2][3]

Clinical:[4]

  • Slow growing.
  • Uncommonly recur.
  • Usually painless.

Clinical DDx:

Gross

Microscopic

Features:[5]

  • Hypercellular zones and hypocellular edematous zones.
  • Small blood vessels (~20 micrometers) - no large blood vessels - key feature.
  • Myxoid stroma - key feature.
  • Small stellate cell/spindle cells without significant nuclear atypia.

DDx:

Images

  • AMF - low mag.

  • AMF - intermed. mag.

  • AMF - high mag.

  • AMF - very high mag.

www:

IHC

  • Desmin +ve.[4]
  • Vimentin +ve.[4]
  • SMA +ve.
  • S-100 -ve.
  • Actin -ve.
  • CD34 -ve.

See also

References

  1. ↑ Cao D, Srodon M, Montgomery EA, Kurman RJ (April 2005). "Lipomatous variant of angiomyofibroblastoma: report of two cases and review of the literature". Int. J. Gynecol. Pathol. 24 (2): 196–200. PMID 15782077.
  2. ↑ 2.0 2.1 Ding, G.; Yu, Y.; Jin, M.; Xu, J.; Zhang, Z. (Feb 2014). "Angiomyofibroblastoma-like tumor of the scrotum: A case report and literature review.". Oncol Lett 7 (2): 435-438. doi:10.3892/ol.2013.1741. PMID 24396463.
  3. ↑ Butt, Z.; Slatnik, J.; Estey, EP. (Dec 2013). "Robotic assisted laparoscopic excision of a pelvic angiomyofibroblastoma-like tumor.". Can J Urol 20 (6): 7067-9. PMID 24331351.
  4. ↑ 4.0 4.1 4.2 4.3 Seo, JW.; Lee, KA.; Yoon, NR.; Lee, JW.; Kim, BG.; Bae, DS. (Sep 2013). "Angiomyofibroblastoma of the vulva.". Obstet Gynecol Sci 56 (5): 349-51. doi:10.5468/ogs.2013.56.5.349. PMID 24328028.
  5. ↑ Fletcher, CD.; Tsang, WY.; Fisher, C.; Lee, KC.; Chan, JK. (Apr 1992). "Angiomyofibroblastoma of the vulva. A benign neoplasm distinct from aggressive angiomyxoma.". Am J Surg Pathol 16 (4): 373-82. PMID 1314521.
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