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Difference between revisions of "Angiomyofibroblastoma"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Angiomyofibroblastoma humpath 4.jpg | |||
| Width = | |||
| Caption = Angiomyofibroblastoma. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = hypercellular zones and hypocellular edematous zones, small blood vessels (~20 micrometers) - no large blood vessels, [[myxoid stroma]], small stellate cell/spindle cells without significant nuclear atypia | |||
| Subtypes = | |||
| LMDDx = [[aggressive angiomyxoma]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = well-circumscribed | |||
| Grossing = | |||
| Site = female pelvis ([[vulva]]), case reports of similar lesion in males | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = slow growing, usu. not painful | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = very rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = [[Bartholin cyst]], [[aggressive angiomyxoma]] | |||
| Tx = | |||
}} | |||
'''Angiomyofibroblastoma''', abbreviated '''AMF''',<ref name=pmid15782077>{{cite journal |author=Cao D, Srodon M, Montgomery EA, Kurman RJ |title=Lipomatous variant of angiomyofibroblastoma: report of two cases and review of the literature |journal=Int. J. Gynecol. Pathol. |volume=24 |issue=2 |pages=196–200 |year=2005 |month=April |pmid=15782077 |doi= |url=}}</ref> is rare uncommon [[soft tissue lesion]] of the [[vulva]]. | |||
==General== | |||
*Uncommon. | |||
*Similar lesions reported in males.<ref name=pmid24396463>{{Cite journal | last1 = Ding | first1 = G. | last2 = Yu | first2 = Y. | last3 = Jin | first3 = M. | last4 = Xu | first4 = J. | last5 = Zhang | first5 = Z. | title = Angiomyofibroblastoma-like tumor of the scrotum: A case report and literature review. | journal = Oncol Lett | volume = 7 | issue = 2 | pages = 435-438 | month = Feb | year = 2014 | doi = 10.3892/ol.2013.1741 | PMID = 24396463 }}</ref><ref>{{Cite journal | last1 = Butt | first1 = Z. | last2 = Slatnik | first2 = J. | last3 = Estey | first3 = EP. | title = Robotic assisted laparoscopic excision of a pelvic angiomyofibroblastoma-like tumor. | journal = Can J Urol | volume = 20 | issue = 6 | pages = 7067-9 | month = Dec | year = 2013 | doi = | PMID = 24331351 }}</ref> | |||
Clinical:<ref name=pmid24328028/> | |||
*Slow growing. | |||
*Uncommonly recur. | |||
*Usually painless. | |||
Clinical DDx: | |||
*[[Bartholin cyst]]. | |||
==Gross== | |||
*[[Vulva|Vulvar lesion]]. | |||
*Well-circumscribed.<ref name=pmid24328028>{{Cite journal | last1 = Seo | first1 = JW. | last2 = Lee | first2 = KA. | last3 = Yoon | first3 = NR. | last4 = Lee | first4 = JW. | last5 = Kim | first5 = BG. | last6 = Bae | first6 = DS. | title = Angiomyofibroblastoma of the vulva. | journal = Obstet Gynecol Sci | volume = 56 | issue = 5 | pages = 349-51 | month = Sep | year = 2013 | doi = 10.5468/ogs.2013.56.5.349 | PMID = 24328028 }}</ref> | |||
==Microscopic== | |||
Features:<ref name=pmid1314521>{{Cite journal | last1 = Fletcher | first1 = CD. | last2 = Tsang | first2 = WY. | last3 = Fisher | first3 = C. | last4 = Lee | first4 = KC. | last5 = Chan | first5 = JK. | title = Angiomyofibroblastoma of the vulva. A benign neoplasm distinct from aggressive angiomyxoma. | journal = Am J Surg Pathol | volume = 16 | issue = 4 | pages = 373-82 | month = Apr | year = 1992 | doi = | PMID = 1314521 }}</ref> | |||
*Hypercellular zones and hypocellular edematous zones. | |||
*Small blood vessels (~20 micrometers) - no large blood vessels - '''key feature'''. | |||
*[[Myxoid stroma]] - '''key feature'''. | |||
*Small stellate cell/spindle cells without significant nuclear atypia. | |||
DDx: | |||
*[[Aggressive angiomyxoma]] - less cellular, large blood vessels. | |||
===Images=== | |||
<gallery> | |||
Image:Angiomyofibroblastoma humpath 1.jpg | AMF - low mag. | |||
Image:Angiomyofibroblastoma humpath 2.jpg | AMF - intermed. mag. | |||
Image:Angiomyofibroblastoma humpath 3.jpg | AMF - high mag. | |||
Image:Angiomyofibroblastoma humpath 4.jpg | AMF - very high mag. | |||
</gallery> | |||
www: | |||
*[http://www.webpathology.com/image.asp?case=544&n=4 Angiomyofibroblastoma (webpathology.com)] | |||
*[http://www.webpathology.com/image.asp?n=5&Case=544 Angiomyofibroblastoma - high mag. (webpathology.com)]. | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881198/figure/f2-ol-07-02-0435/ Angiomyofibroblastoma-like tumour of scrotum (nih.gov)].<ref name=pmid24396463/> | |||
==IHC== | |||
*Desmin +ve.<ref name=pmid24328028/> | |||
*Vimentin +ve.<ref name=pmid24328028/> | |||
*SMA +ve. | |||
*S-100 -ve. | |||
*Actin -ve. | |||
*CD34 -ve. | |||
==See also== | |||
*[[Soft tissue lesions]]. | |||
*[[Vulva]]. | |||
*[[Scrotum]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Soft tissue lesions]] | |||