Difference between revisions of "Angiokeratoma"

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#redirect [[Non-malignant_skin_disease#Angiokeratoma]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Angiokeratoma_-_low_mag.jpg
| Width      =
| Caption    = Angiokeratoma. [[H&E stain]].
| Synonyms  =
| Micro      = ectatic superficial dermal vessels with overlying hyperkeratosis (thick stratum corneum); should have "epidermal collarette" (vascular space is surrounded by epidermis on three sides)
| Subtypes  =
| LMDDx      = [[venous lake]]
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[skin]]
| Assdx      =
| Syndromes  = [[Fabry disease]]
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = uncommon
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = benign
| Other      =
| ClinDDx    = [[melanocytic lesions]], other [[vascular lesions]]
| Tx        =
}}
'''Angiokeratoma''' is a benign [[skin]] lesion.


==General==
*Rare.
*May be seen in the context of [[Fabry disease]].<ref name=pmid16403380/>
Notes:
*Shouldn't be confused with ''[[angiofibroma]]'' which is associated [[tuberous sclerosis]].
==Gross==
*Dark lesions.
Clinical DDx:
*[[Melanocytic lesions]].
===Images===
<gallery>
Image:Angiokeratoma_of_the_Scrotum_7.jpg | Angiokeratoma. (WC)
</gallery>
==Microscopic==
Features:<ref name=pmid16403380>{{Cite journal  | last1 = Karen | first1 = JK. | last2 = Hale | first2 = EK. | last3 = Ma | first3 = L. | title = Angiokeratoma corporis diffusum (Fabry disease). | journal = Dermatol Online J | volume = 11 | issue = 4 | pages = 8 | month =  | year = 2005 | doi =  | PMID = 16403380 }}</ref>
#Ectatic superficial dermal vessels.
#Overlying hyperkeratosis (thick stratum corneum).
*Should have "epidermal collarette".<ref name=Ref_Derm548>{{Ref Derm|548}}</ref>
**Vascular space surrounded by epidermis on three sides.
Others features:{{fact}}
*Irregular [[acanthosis]].
*Longer rete ridges.
DDx:
*[[Venous lake]].
*Angiokeratoma-like changes in [[lichen sclerosus]].<ref name=pmid19187108>{{Cite journal  | last1 = Luzar | first1 = B. | last2 = Neil | first2 = SM. | last3 = Calonje | first3 = E. | title = Angiokeratoma-like changes in extragenital and genital lichen sclerosus. | journal = J Cutan Pathol | volume = 36 | issue = 5 | pages = 540-2 | month = May | year = 2009 | doi = 10.1111/j.1600-0560.2008.01091.x | PMID = 19187108 }}</ref>
===Images===
<gallery>
Image:Angiokeratoma_-_low_mag.jpg | Angiokeratoma - low mag. (WC/Nephron)
Image:Angiokeratoma_-_intermed_mag.jpg | Angiokeratoma - intermed. mag. (WC/Nephron)
Image:Angiokeratoma_-_high_mag.jpg | Angiokeratoma - high mag. (WC/Nephron)
</gallery>
www:
*[http://www.pathologyoutlines.com/images/skintumorangiokerat1.jpg Angiokeratoma (pathologyoutlines.com)].
==Sign out==
<pre>
SKIN LESION, LEFT POPITEAL FOSSA, PUNCH BIOPSY:
- ANGIOKERATOMA.
</pre>
==See also==
*[[Non-malignant skin disease]].
==References==
{{Reflist|2}}
[[Category:Non-malignant skin disease]]
[[Category:Diagnosis]]
[[Category:Diagnosis]]

Latest revision as of 17:36, 15 February 2015

Angiokeratoma
Diagnosis in short

Angiokeratoma. H&E stain.

LM ectatic superficial dermal vessels with overlying hyperkeratosis (thick stratum corneum); should have "epidermal collarette" (vascular space is surrounded by epidermis on three sides)
LM DDx venous lake
Site skin

Syndromes Fabry disease

Prevalence uncommon
Prognosis benign
Clin. DDx melanocytic lesions, other vascular lesions

Angiokeratoma is a benign skin lesion.

General

Notes:

Gross

  • Dark lesions.

Clinical DDx:

Images

Microscopic

Features:[1]

  1. Ectatic superficial dermal vessels.
  2. Overlying hyperkeratosis (thick stratum corneum).
  • Should have "epidermal collarette".[2]
    • Vascular space surrounded by epidermis on three sides.

Others features:[citation needed]

DDx:

Images

www:

Sign out

SKIN LESION, LEFT POPITEAL FOSSA, PUNCH BIOPSY:
- ANGIOKERATOMA.

See also

References

  1. 1.0 1.1 Karen, JK.; Hale, EK.; Ma, L. (2005). "Angiokeratoma corporis diffusum (Fabry disease).". Dermatol Online J 11 (4): 8. PMID 16403380.
  2. Busam, Klaus J. (2009). Dermatopathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Saunders. pp. 548. ISBN 978-0443066542.
  3. Luzar, B.; Neil, SM.; Calonje, E. (May 2009). "Angiokeratoma-like changes in extragenital and genital lichen sclerosus.". J Cutan Pathol 36 (5): 540-2. doi:10.1111/j.1600-0560.2008.01091.x. PMID 19187108.