Difference between revisions of "Alpha-fetoprotein"

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{{ Infobox immunostain
| Name      = {{PAGENAME}}
| Image      =
| Width      =
| Caption    =
| Abbrev    = AFP
| Synonyms  =
| Similar    =
| Clones    =     
| Use        =
| Subspecial = [[genitourinary pathology]], [[gastrointestinal pathology]] 
| Pattern    =
| Positive  = [[yolk sac tumour]], [[hepatocellular carcinoma]]
| Negative  =
| Other      = common serum tumour marker
}}
'''Alpha-fetoprotein''', abbreviated '''AFP''', is plasma protein seen in fetal life and produced by various tumours.
'''Alpha-fetoprotein''', abbreviated '''AFP''', is plasma protein seen in fetal life and produced by various tumours.


==Elevated AFP - classic causes==
==Elevated AFP - classic causes==
*[[Yolk sac tumour]].
*[[Yolk sac tumour]].
*[[Hepatocellular carcinoma]].
*[[Hepatocellular carcinoma]].<ref name=pmid26157947>{{Cite journal  | last1 = Ip | first1 = S. | last2 = Schaeffer | first2 = DF. | last3 = Yoshida | first3 = EM. | last4 = Kwan | first4 = WP. | title = Alpha Fetoprotein-Secreting Gastric Cancer in the Setting of Chronic Hepatitis B: The Role of Endoscopy. | journal = ACG Case Rep J | volume = 2 | issue = 3 | pages = 152-4 | month = Apr | year = 2015 | doi = 10.14309/crj.2015.38 | PMID = 26157947 }}</ref>


==Uncommon==
==Uncommon==
*[[Rectal carcinoma]].<ref name=pmid25962419>{{Cite journal  | last1 = Anzai | first1 = H. | last2 = Kazama | first2 = S. | last3 = Kiyomatsu | first3 = T. | last4 = Nishikawa | first4 = T. | last5 = Tanaka | first5 = T. | last6 = Tanaka | first6 = J. | last7 = Hata | first7 = K. | last8 = Kawai | first8 = K. | last9 = Yamaguchi | first9 = H. | title = Alpha-fetoprotein-producing early rectal carcinoma: a rare case report and review. | journal = World J Surg Oncol | volume = 13 | issue =  | pages = 180 | month =  | year = 2015 | doi = 10.1186/s12957-015-0590-x | PMID = 25962419 }}</ref>
*[[Rectal carcinoma]].<ref name=pmid25962419>{{Cite journal  | last1 = Anzai | first1 = H. | last2 = Kazama | first2 = S. | last3 = Kiyomatsu | first3 = T. | last4 = Nishikawa | first4 = T. | last5 = Tanaka | first5 = T. | last6 = Tanaka | first6 = J. | last7 = Hata | first7 = K. | last8 = Kawai | first8 = K. | last9 = Yamaguchi | first9 = H. | title = Alpha-fetoprotein-producing early rectal carcinoma: a rare case report and review. | journal = World J Surg Oncol | volume = 13 | issue =  | pages = 180 | month =  | year = 2015 | doi = 10.1186/s12957-015-0590-x | PMID = 25962419 }}</ref>
*[[Gastric carcinoma]].<ref name=pmid26157947>{{Cite journal  | last1 = Ip | first1 = S. | last2 = Schaeffer | first2 = DF. | last3 = Yoshida | first3 = EM. | last4 = Kwan | first4 = WP. | title = Alpha Fetoprotein-Secreting Gastric Cancer in the Setting of Chronic Hepatitis B: The Role of Endoscopy. | journal = ACG Case Rep J | volume = 2 | issue = 3 | pages = 152-4 | month = Apr | year = 2015 | doi = 10.14309/crj.2015.38 | PMID = 26157947 }}</ref>
*[[Gastric carcinoma]].<ref name=pmid26157947>{{Cite journal  | last1 = Ip | first1 = S. | last2 = Schaeffer | first2 = DF. | last3 = Yoshida | first3 = EM. | last4 = Kwan | first4 = WP. | title = Alpha Fetoprotein-Secreting Gastric Cancer in the Setting of Chronic Hepatitis B: The Role of Endoscopy. | journal = ACG Case Rep J | volume = 2 | issue = 3 | pages = 152-4 | month = Apr | year = 2015 | doi = 10.14309/crj.2015.38 | PMID = 26157947 }}</ref><ref>{{cite journal |authors=Tatli AM, Urakci Z, Kalender ME, Arslan H, Tastekin D, Kaplan MA |title=Alpha-fetoprotein (AFP) elevation gastric adenocarcinoma and importance of AFP change in tumor response evaluation |journal=Asian Pac J Cancer Prev |volume=16 |issue=5 |pages=2003–7 |date=2015 |pmid=25773802 |doi=10.7314/apjcp.2015.16.5.2003 |url=}}</ref>


==See also==
==See also==

Latest revision as of 23:47, 10 October 2023

Alpha-fetoprotein
Immunostain in short
Abbreviation AFP
Subspeciality genitourinary pathology, gastrointestinal pathology
Positive yolk sac tumour, hepatocellular carcinoma
Other common serum tumour marker

Alpha-fetoprotein, abbreviated AFP, is plasma protein seen in fetal life and produced by various tumours.

Elevated AFP - classic causes

Uncommon

See also

References

  1. 1.0 1.1 Ip, S.; Schaeffer, DF.; Yoshida, EM.; Kwan, WP. (Apr 2015). "Alpha Fetoprotein-Secreting Gastric Cancer in the Setting of Chronic Hepatitis B: The Role of Endoscopy.". ACG Case Rep J 2 (3): 152-4. doi:10.14309/crj.2015.38. PMID 26157947.
  2. Anzai, H.; Kazama, S.; Kiyomatsu, T.; Nishikawa, T.; Tanaka, T.; Tanaka, J.; Hata, K.; Kawai, K. et al. (2015). "Alpha-fetoprotein-producing early rectal carcinoma: a rare case report and review.". World J Surg Oncol 13: 180. doi:10.1186/s12957-015-0590-x. PMID 25962419.
  3. Tatli AM, Urakci Z, Kalender ME, Arslan H, Tastekin D, Kaplan MA (2015). "Alpha-fetoprotein (AFP) elevation gastric adenocarcinoma and importance of AFP change in tumor response evaluation". Asian Pac J Cancer Prev 16 (5): 2003–7. doi:10.7314/apjcp.2015.16.5.2003. PMID 25773802.