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Difference between revisions of "Adipocytic tumours"
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→Myxoid liposarcoma: tweak
(→Gross: fix) |
(→Myxoid liposarcoma: tweak) |
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=====Myxoid liposarcoma===== | =====Myxoid liposarcoma===== | ||
*[[AKA]] ''myxoid/round cell liposarcoma''. | |||
======Gross====== | |||
Location:<ref name=pmid22052112>{{Cite journal | last1 = Moreau | first1 = LC. | last2 = Turcotte | first2 = R. | last3 = Ferguson | first3 = P. | last4 = Wunder | first4 = J. | last5 = Clarkson | first5 = P. | last6 = Masri | first6 = B. | last7 = Isler | first7 = M. | last8 = Dion | first8 = N. | last9 = Werier | first9 = J. | title = Myxoid\Round Cell Liposarcoma (MRCLS) Revisited: An Analysis of 418 Primarily Managed Cases. | journal = Ann Surg Oncol | volume = 19 | issue = 4 | pages = 1081-1088 | month = Apr | year = 2012 | doi = 10.1245/s10434-011-2127-z | PMID = 22052112 }}</ref> | Location:<ref name=pmid22052112>{{Cite journal | last1 = Moreau | first1 = LC. | last2 = Turcotte | first2 = R. | last3 = Ferguson | first3 = P. | last4 = Wunder | first4 = J. | last5 = Clarkson | first5 = P. | last6 = Masri | first6 = B. | last7 = Isler | first7 = M. | last8 = Dion | first8 = N. | last9 = Werier | first9 = J. | title = Myxoid\Round Cell Liposarcoma (MRCLS) Revisited: An Analysis of 418 Primarily Managed Cases. | journal = Ann Surg Oncol | volume = 19 | issue = 4 | pages = 1081-1088 | month = Apr | year = 2012 | doi = 10.1245/s10434-011-2127-z | PMID = 22052112 }}</ref> | ||
*90% in lower limb. | *90% in lower limb. | ||
*81% deep. | *81% deep. | ||
Microscopic | ======Microscopic====== | ||
Features: | |||
*Chickenwire-type blood vessels. | *Chickenwire-type blood vessels. | ||
*Clear spaces. | *Clear spaces. | ||
*Adipocytes - may be rare. | *Adipocytes - may be rare. | ||
DDx: | |||
*[[Low-grade fibromyxoid sarcoma]]. | |||
Images: | |||
*[http://radiographics.rsna.org/content/20/4/1007/F4.expansion.html Myxoid liposarcoma (rsna.org)]. | |||
*[http://www.cap.org/apps/cap.portal?_nfpb=true&cntvwrPtlt_actionOverride=%2Fportlets%2FcontentViewer%2Fshow&_windowLabel=cntvwrPtlt&cntvwrPtlt{actionForm.contentReference}=cap_foundation%2FcaseOfMonth%2Ffeb13%2Ffeb_2013_cotm_diagnosis.html&_state=maximized&_pageLabel=cntvwr Myxoid liposarcoma (cap.org)]. | |||
======Molecular====== | |||
Typically has a [[translocations|translocation]]: | Typically has a [[translocations|translocation]]: | ||
*t(12;16)(q13;p11) TLS-CHOP.<ref name=pmid7805034>{{Cite journal | last1 = Knight | first1 = JC. | last2 = Renwick | first2 = PJ. | last3 = Dal Cin | first3 = P. | last4 = Van den Berghe | first4 = H. | last5 = Fletcher | first5 = CD. | title = Translocation t(12;16)(q13;p11) in myxoid liposarcoma and round cell liposarcoma: molecular and cytogenetic analysis. | journal = Cancer Res | volume = 55 | issue = 1 | pages = 24-7 | month = Jan | year = 1995 | doi = | PMID = 7805034 }}</ref> | *t(12;16)(q13;p11) TLS-CHOP.<ref name=pmid7805034>{{Cite journal | last1 = Knight | first1 = JC. | last2 = Renwick | first2 = PJ. | last3 = Dal Cin | first3 = P. | last4 = Van den Berghe | first4 = H. | last5 = Fletcher | first5 = CD. | title = Translocation t(12;16)(q13;p11) in myxoid liposarcoma and round cell liposarcoma: molecular and cytogenetic analysis. | journal = Cancer Res | volume = 55 | issue = 1 | pages = 24-7 | month = Jan | year = 1995 | doi = | PMID = 7805034 }}</ref> | ||
*May have the translocation usually seen in [[clear cell sarcoma]]: | *May have the translocation usually seen in [[clear cell sarcoma]]: | ||
*t(12;22)(q13;q12) EWS-ATF1.<ref name=pmid21115923>{{Cite journal | last1 = Suzuki | first1 = K. | last2 = Matsui | first2 = Y. | last3 = Endo | first3 = K. | last4 = Kubo | first4 = T. | last5 = Hasegawa | first5 = T. | last6 = Kimura | first6 = T. | last7 = Ohtani | first7 = O. | last8 = Yasui | first8 = N. | title = Myxoid liposarcoma with EWS-CHOP type 1 fusion gene. | journal = Anticancer Res | volume = 30 | issue = 11 | pages = 4679-83 | month = Nov | year = 2010 | doi = | PMID = 21115923 }}</ref> | *t(12;22)(q13;q12) EWS-ATF1.<ref name=pmid21115923>{{Cite journal | last1 = Suzuki | first1 = K. | last2 = Matsui | first2 = Y. | last3 = Endo | first3 = K. | last4 = Kubo | first4 = T. | last5 = Hasegawa | first5 = T. | last6 = Kimura | first6 = T. | last7 = Ohtani | first7 = O. | last8 = Yasui | first8 = N. | title = Myxoid liposarcoma with EWS-CHOP type 1 fusion gene. | journal = Anticancer Res | volume = 30 | issue = 11 | pages = 4679-83 | month = Nov | year = 2010 | doi = | PMID = 21115923 }}</ref> | ||
=====Dedifferentiated liposarcoma===== | =====Dedifferentiated liposarcoma===== | ||