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Difference between revisions of "Adenomatoid tumour"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Adenomatoid_tumour_-b-_very_high_mag.jpg | |||
| Width = | |||
| Caption = Adenomatoid tumour. [[H&E stain]]. | |||
| Micro = small tubulocystic spaces lined by unremarkable mesothelium; the pseudotubular spaces are crossed by "thread-like bridging strands, usu. well-circumscribed | |||
| Subtypes = | |||
| LMDDx = [[lymphangioma]], [[leiomyoma]], [[vascular tumours]] | |||
| Stains = | |||
| IHC = calretinin +ve, CK7 +ve, AE1/AE3 +ve, WT1 +ve, CD31 -ve, desmin -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[uterus]], adnexa ([[fallopian tube]]/[[ovaries]]), others | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = [[leiomyoma]], other adenxal masses | |||
}} | |||
'''Adenomatoid tumour''' is a rare benign tumour derived from the mesothelium. | |||
It should '''not''' be confused with the [[bone tumour]] ''[[adamantinoma]]''. | |||
==General== | |||
*Grossly mimics leiomyoma.<ref name=pmid8543111>{{Cite journal | last1 = Huang | first1 = CC. | last2 = Chang | first2 = DY. | last3 = Chen | first3 = CK. | last4 = Chou | first4 = YY. | last5 = Huang | first5 = SC. | title = Adenomatoid tumor of the female genital tract. | journal = Int J Gynaecol Obstet | volume = 50 | issue = 3 | pages = 275-80 | month = Sep | year = 1995 | doi = | PMID = 8543111 }} | |||
</ref> | |||
*Benign tumour - derived from mesothelium. | |||
*May be seen para[[testicle|testicular]].<ref name=pmid20223139>{{Cite journal | last1 = González Resina | first1 = R. | last2 = Carranza Carranza | first2 = A. | last3 = Congregado Córdoba | first3 = J. | last4 = Conde Sánchez | first4 = JM. | last5 = Congregado Ruiz | first5 = CB. | last6 = Medina López | first6 = R. | title = [Paratesticular adenomatoid tumor: a report of nine cases]. | journal = Actas Urol Esp | volume = 34 | issue = 1 | pages = 95-100 | month = Jan | year = 2010 | doi = | PMID = 20223139 }} | |||
</ref> | |||
==Microscopic== | |||
Features:<ref>{{Ref GP|346}}</ref> | |||
*Well-circumscribed lesion; however, ''not'' encapsulated. | |||
*Small tubulocystic spaces lined by cytologically normal mesothelium. | |||
**These pseudotubular spaces are crossed by "thread-like bridging strands" - '''key feature'''.<ref name=pmid19543245>{{Cite journal | last1 = Sangoi | first1 = AR. | last2 = McKenney | first2 = JK. | last3 = Schwartz | first3 = EJ. | last4 = Rouse | first4 = RV. | last5 = Longacre | first5 = TA. | title = Adenomatoid tumors of the female and male genital tracts: a clinicopathological and immunohistochemical study of 44 cases. | journal = Mod Pathol | volume = 22 | issue = 9 | pages = 1228-35 | month = Sep | year = 2009 | doi = 10.1038/modpathol.2009.90 | PMID = 19543245 }}</ref><ref name=pmid14571427>{{Cite journal | last1 = Hes | first1 = O. | last2 = Perez-Montiel | first2 = DM. | last3 = Alvarado Cabrero | first3 = I. | last4 = Zamecnik | first4 = M. | last5 = Podhola | first5 = M. | last6 = Sulc | first6 = M. | last7 = Hora | first7 = M. | last8 = Mukensnabl | first8 = P. | last9 = Zalud | first9 = R. | title = Thread-like bridging strands: a morphologic feature present in all adenomatoid tumors. | journal = Ann Diagn Pathol | volume = 7 | issue = 5 | pages = 273-7 | month = Oct | year = 2003 | doi = | PMID = 14571427 }}</ref> | |||
DDx: | |||
*[[Lymphangioma]]. | |||
*[[Leiomyoma]], esp. lipoleiomyoma. | |||
*[[Vascular tumours]]. | |||
===Images=== | |||
<gallery> | |||
Image:Adenomatoid_tumour_-_low_mag.jpg | Adenomatoid tumour - low mag. (WC) | |||
Image:Adenomatoid_tumour_-_intermed_mag.jpg | Adenomatoid tumour - intermed. mag. (WC) | |||
Image:Adenomatoid_tumour_-_high_mag.jpg | Adenomatoid tumour - high mag. (WC) | |||
Image:Adenomatoid_tumour_-b-_very_high_mag.jpg | Adenomatoid tumour - very high mag. (WC) | |||
</gallery> | |||
==IHC== | |||
Features:<ref name=pmid16548294>{{Cite journal | last1 = Canedo-Patzi | first1 = AM. | last2 = León-Bojorge | first2 = B. | last3 = de Ortíz-Hidalgo | first3 = C. | title = [Adenomatoid tumor of the genital tract. Clinical, pathological and immunohistochemical study in 9 cases] | journal = Gac Med Mex | volume = 142 | issue = 1 | pages = 59-66 | month = | year = | doi = | PMID = 16548294 }} | |||
</ref> | |||
*Calretinin +ve. | |||
*AE1/AE3 +ve. | |||
*CK7 +ve.<ref name=pmid22553816>{{Cite journal | last1 = Terada | first1 = T. | title = An immunohistochemical study of adenomatoid tumors of the uterus and fallopian tube. | journal = Appl Immunohistochem Mol Morphol | volume = 20 | issue = 2 | pages = 173-6 | month = Mar | year = 2012 | doi = | PMID = 22553816 }}</ref> | |||
Others:<ref name=pmid22553816/> | |||
*CK20 -ve. | |||
*EMA -ve. | |||
*HMB-45 -ve. | |||
*Vimentin -ve. | |||
*Desmin -ve. | |||
*CD31 -ve. | |||
*CD34 -ve. | |||
*WT1 +ve.<ref name=pmid15084840>{{Cite journal | last1 = Schwartz | first1 = EJ. | last2 = Longacre | first2 = TA. | title = Adenomatoid tumors of the female and male genital tracts express WT1. | journal = Int J Gynecol Pathol | volume = 23 | issue = 2 | pages = 123-8 | month = Apr | year = 2004 | doi = | PMID = 15084840 }}</ref> | |||
==See also== | |||
*[[Uterine tumours]]. | |||
*[[Fallopian tube]]. | |||
*[[Benign multicystic mesothelioma]]. | |||
*[[Malignant mesothelioma]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | |||
[[Category:Gynecologic pathology]] | |||