Adamantinoma

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Adamantinoma
Diagnosis in short

Adamantinoma. H&E stain.
Site bone - usu. tibia or fibula.

Prevalence uncommon
Prognosis benign +/-locally aggressive
Clin. DDx osteosarcoma

Adamantinoma is an uncommon benign bone tumour. It should not be confused with adenomatoid tumour.

General

Features:[1]

  • Rare: < 1% of bone tumours.
  • 25-35 years old.
  • Benign, may be locally aggressive.
  • Cousin of ameloblastoma. (???)

Gross

  • Tibia or fibula.

Radiology

  • Intracortical, radiolucent.

Microscopic

Features:

  • Biphasic tumour:
    1. Fibrous/spindle cell component.
    2. Epithelial component.

DDx:[2]

Images

www:

IHC

Features:[2]

  • CK14 +ve (HMWK).[4]
  • CK19 +ve (LMWK).
  • CK8/18 -ve (LMWK).

See also

References

  1. Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 650. ISBN 978-0781765275.
  2. 2.0 2.1 URL: http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970057-2. Accessed on: 28 April 2011.
  3. URL: http://southbaypath.org/CaseImages/sb5260/sb5260.htm. Accessed on: 7 December 2010.
  4. URL: http://www.nordiqc.org/Epitopes/Cytokeratins/cytokeratins.htm. Accessed on: 28 April 2011.