Epstein-Barr virus
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Micrograph showing an EBER (Epstein-Barr virus (EBV)-encoded small RNAs) positive nasopharyngeal carcinoma. (WC)
The Epstein-Barr virus, abbreviated EBV, is virus implicated in several types of cancer.
General
- Cases mononucleosis.
- Part of the herpes group of viruses.[1]
Note:
- The virus is Epstein... the tricuspid abnormality is Ebstein.
Associations
Cancer:[2]
- Classical Hodgkin lymphoma.
- Burkitt lymphoma.
- Nasopharyngeal carcinoma.
- B cell lymphomas -- in immunosuppressed individuals.
- Leiomyoma and leiomyosarcoma in the context of HIV.[3]
- Extranodal NK/T-cell lymphoma, nasal type.
- Stomach carcinoma[4] - thought to be associated with ~10% of gastric carcinomas.[5]
Other:
- Hemophagocytic syndrome.[6]
- Epstein-Barr virus-associated smooth muscle tumour - very uncommon, in immunoincompetent individuals.[7]
- EBV-associated colitis[8] - may mimic IBD.[9]
EBV infection cycle. (WC)
Microscopic
Features:
- Variable - see specific pathologies in Associations section.
- +/-Atypical lymphocytes.
- +/-Hemophagocytosis (uncommon).
Images:
IHC
- Mixed population of CD3 & CD20 -- in benign.
Molecular
- EBER +ve - in situ hybridization for RNA fragments in EBV.[10]
- EBER = Epstein-Barr virus (EBV)-encoded small RNAs.[11]
See also
References
- ↑ URL: http://www.meddean.luc.edu/lumen/MedEd/orfpath/herpes.htm. Accessed on: 14 April 2011.
- ↑ Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 169. ISBN 978-1416054542.
- ↑ McClain, KL.; Joshi, VV.; Murphy, SB. (Oct 1996). "Cancers in children with HIV infection.". Hematol Oncol Clin North Am 10 (5): 1189-201. PMID 8880205.
- ↑ Sun K, Jia K, Lv H, Wang SQ, Wu Y, Lei H, Chen X (2020). "EBV-Positive Gastric Cancer: Current Knowledge and Future Perspectives". Front Oncol 10: 583463. doi:10.3389/fonc.2020.583463. PMC 7769310. PMID 33381453. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769310/.
- ↑ Iizasa H, Nanbo A, Nishikawa J, Jinushi M, Yoshiyama H (December 2012). "Epstein-Barr Virus (EBV)-associated gastric carcinoma". Viruses 4 (12): 3420–39. doi:10.3390/v4123420. PMC 3528272. PMID 23342366. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528272/.
- ↑ Jin YK, Xie ZD, Yang S, Lu G, Shen KL (June 2010). "Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis: a retrospective study of 78 pediatric cases in mainland of China". Chin. Med. J. 123 (11): 1426–30. PMID 20819601.
- ↑ Deyrup, AT.; Lee, VK.; Hill, CE.; Cheuk, W.; Toh, HC.; Kesavan, S.; Chan, EW.; Weiss, SW. (Jan 2006). "Epstein-Barr virus-associated smooth muscle tumors are distinctive mesenchymal tumors reflecting multiple infection events: a clinicopathologic and molecular analysis of 29 tumors from 19 patients.". Am J Surg Pathol 30 (1): 75-82. PMID 16330945.
- ↑ Weinberg, I.; Neuman, T.; Margalit, M.; Ayman, F.; Wolf, DG.; Ben-Yehuda, A. (May 2009). "Epstein-barr virus-related diarrhea or exacerbation of inflammatory bowel disease: diagnostic dilemma.". J Clin Microbiol 47 (5): 1588-90. doi:10.1128/JCM.02477-08. PMID 19279175. http://jcm.asm.org/content/47/5/1588.full.
- ↑ Karlitz, JJ.; Li, ST.; Holman, RP.; Rice, MC. (Jan 2011). "EBV-associated colitis mimicking IBD in an immunocompetent individual.". Nat Rev Gastroenterol Hepatol 8 (1): 50-4. doi:10.1038/nrgastro.2010.192. PMID 21119609.
- ↑ Tornóczky, T.; Kelényi, G.; Pajor, L. (1998). "EBER oligonucleotide RNA in situ hybridization in EBV associated neoplasms.". Pathol Oncol Res 4 (3): 201-5. PMID 9761938.
- ↑ Iwakiri D, Takada K (2010). "Role of EBERs in the pathogenesis of EBV infection". Adv. Cancer Res. 107: 119–36. doi:10.1016/S0065-230X(10)07004-1. PMID 20399962.