TDP-43

From Libre Pathology
Revision as of 11:54, 5 July 2018 by Jensflorian (talk | contribs) (+cte)
Jump to navigation Jump to search

TAR-DNA-binding Protein 43, abbreviated TDP-43 is a neuropathology immunostain used in neurodegenerative diseases.

  • Nuclear staining.
TDP-43
Immunostain in short

TDP-43 staining in FTLD-TDP43. (WC)
Normal staining pattern nuclear staining (physiological)
Positive cytoplasmatic staining (pathological)

Inclusion morphology

  • fine / coarse skeins.
  • dot-like.
  • dense-round inclusions.

Inclusions found


Images

See also

References

  1. Wilson, AC.; Dugger, BN.; Dickson, DW.; Wang, DS. (Jan 2011). "TDP-43 in aging and Alzheimer's disease - a review.". Int J Clin Exp Pathol 4 (2): 147-55. PMID 21326809.
  2. McKee, AC.; Cairns, NJ.; Dickson, DW.; Folkerth, RD.; Keene, CD.; Litvan, I.; Perl, DP.; Stein, TD. et al. (Jan 2016). "The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy.". Acta Neuropathol 131 (1): 75-86. doi:10.1007/s00401-015-1515-z. PMID 26667418.
  3. Wilson, AC.; Dugger, BN.; Dickson, DW.; Wang, DS. (Jan 2011). "TDP-43 in aging and Alzheimer's disease - a review.". Int J Clin Exp Pathol 4 (2): 147-55. PMID 21326809.