P40

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P40
Immunostain in short
Similar stains p63
Use lung (adenocarcinoma vs. squamous)
Normal staining pattern nuclear staining
Positive squamous cell carcinoma, urothelial carcinoma
Negative prostate carcinoma, most lung adenocarcinoma, breast carcinoma

p40 an immunostain that is both sensitive and specific for squamous cell carcinoma.

General

  • Considered superior to p63 as it is more specific.[1]
    • p63 stains a significant number of adenocarcinoma.

Staining

Positive

Negative

See also

References

  1. Bishop, JA.; Teruya-Feldstein, J.; Westra, WH.; Pelosi, G.; Travis, WD.; Rekhtman, N. (Mar 2012). "p40 (ΔNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma.". Mod Pathol 25 (3): 405-15. doi:10.1038/modpathol.2011.173. PMID 22056955.