Serous borderline tumour

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Serous borderline tumour
Diagnosis in short

Serous borderline tumour with a micropapillary pattern. H&E stain.
LM DDx serous cystadenoma, serous carcinoma of the ovary, clear cell carcinoma of the ovary
Site ovary, uterine tube - see ovarian tumours

Prevalence uncommon
Prognosis usually benign, need follow-up
Clin. DDx other ovarian tumours (benign and malignant)
Treatment excision, follow-up

Serous borderline tumour is a Muellerian epithelial ovarian tumour with a behaviour that borders on malignant.

It is also known as serous tumour of low malignant potential, abbreviated SLMP.[1][2]

Serous ovarian tumour of low malignant potential redirects here.[2]

General

  • Usually benign.
  • Require long term follow-up.

Microscopic

Features:[3]

  • Cuboidal to columnar epithelium with mild to moderate atypia.
  • No invasive.
  • "Sparse" mitoses.
  • +/-Psammoma bodies.
  • +/-Micropapillary architecture - often described as a medusa head pattern.

DDx:

Images

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Subclassification

Typical subdivided into:[5]

  • Micropapillary serous borderline tumour.
  • Typical serous borderline tumour (SBOT).

Sign out

Cyst and Right Fallopian Tube, Excision:
     - SEROUS BORDERLINE TUMOUR with micropapillary architecture, see comment.
     - Fallopian tube within normal limits.
     - NEGATIVE for evidence of invasion.

Comment:
The lesion appears to be confined to a cystic structure.

See also

References

  1. Seidman, JD.; Kurman, RJ. (May 2000). "Ovarian serous borderline tumors: a critical review of the literature with emphasis on prognostic indicators.". Hum Pathol 31 (5): 539-57. PMID 10836293.
  2. 2.0 2.1 Dietel, M.; Hauptmann, S. (May 2000). "Serous tumors of low malignant potential of the ovary. 1. Diagnostic pathology.". Virchows Arch 436 (5): 403-12. PMID 10881733.
  3. 3.0 3.1 3.2 Nucci, Marisa R.; Oliva, Esther (2009). Gynecologic Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 399. ISBN 978-0443069208.
  4. Burkholz, KJ.; Wood, BP.; Zuppan, C.. "Best cases from the AFIP: Borderline papillary serous tumor of the right ovary.". Radiographics 25 (6): 1689-92. doi:10.1148/rg.256055015. PMID 16284143.
  5. Park, JY.; Kim, DY.; Kim, JH.; Kim, YM.; Kim, KR.; Kim, YT.; Nam, JH. (Dec 2011). "Micropapillary pattern in serous borderline ovarian tumors: does it matter?". Gynecol Oncol 123 (3): 511-6. doi:10.1016/j.ygyno.2011.08.008. PMID 21917305.