Desquamative interstitial pneumonia

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Desquamative interstitial pneumonia, abbreviated DIP, is a diffuse lung disease that is strongly associated with smoking.

General

  • Thought to be advanced RBILD.
  • Strong association with smoking.[1]
    • Treatment: stop smoking.

Microscopic

Features:

  • Abundant brown pigmented airspace macrophages - smoker's macrophages - key feature.
  • Architecture preserved; "linear fibrosis".

Notes:

  • Some fields of view may be indistinguishable from RBILD.

DDx:

  • Amiodarone toxicity.
  • Fibrotic NSIP.

Images:

Stains

  • Macrophages PAS +ve.

See also

References

  1. ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 93. ISBN 978-0781765275.
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