Renal oncocytosis
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| Renal oncocytosis | |
|---|---|
| Diagnosis in short | |
| LM DDx | other renal tumours with eosinophilic cytoplasm |
| IHC | characteristic of the histologic appearance - stain like oncocytoma, ChRCC and hybrid tumour |
| Gross | multiple brown kidney nodules (bilateral or unilateral) |
| Site | kidney - see kidney tumours |
|
| |
| Syndromes | Birt–Hogg–Dubé syndrome |
|
| |
| Prevalence | rare |
| Radiology | multiple renal tumours |
| Clin. DDx | metastatic disease, multifocal renal cell carcinoma |
Renal oncocytosis is the presence of multiple oncocytic lesions within the kidney.[1]
General
- Rare.
- May be seen in the context of Birt–Hogg–Dubé syndrome or renal failure or may be sporadic.
Gross
- Multiple (unilateral or bilateral) brown-coloured nodules.[1]
Microscopic
Features:
- Any mixture of oncocytic tumours (hybrid tumour, chromophobe renal cell carcinoma, renal oncocytoma).
DDx:
- Hybrid tumour.
- Chromophobe renal cell carcinoma.
- Renal oncocytoma.
- Other renal tumours with eosinophilic cytoplasm.
IHC
- Characteristic of the histologic appearance.[1]
- Stain like renal oncocytomas, chromophobe renal cell carcinomas and hybrid tumours.