Postradiation prostatic carcinoma

From Libre Pathology
Revision as of 05:04, 23 July 2015 by Michael (talk | contribs) (→‎IHC)
Jump to navigation Jump to search

Postradiation prostatic carcinoma, also prostate carcinoma after radiation therapy, is uncommon but may be challenging to diagnose.[1]

General

  • Overcall and undercall are both seen.[1]
  • Commonly missed on core biopsies.
  • History of radiation.

Microscopic

Features:[1]

Note:

  • Nuclear enlargement and prominent nucleoli are prevalent in radiation changes of the prostate. These features are not useful in this context.[1]

DDx:

Images

IHC

  • AMACR +ve.
  • CK5/6 -ve.
  • p63 -ve.

Images

See also

References

  1. 1.0 1.1 1.2 1.3 Cheng, L.; Cheville, JC.; Bostwick, DG. (Oct 1999). "Diagnosis of prostate cancer in needle biopsies after radiation therapy.". Am J Surg Pathol 23 (10): 1173-83. PMID 10524518.
  2. Canfield, SE.; Gans, TH.; Unger, P.; Hall, SJ. (Dec 2001). "Postradiation prostatic sarcoma: de novo carcinogenesis or dedifferentiation of prostatic adenocarcinoma?". Tech Urol 7 (4): 294-5. PMID 11763492.