Glycogenic acanthosis of the esophagus

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Glycogenic acanthosis of the esophagus is an uncommon benign change of the esophagus with a distinctive endoscopic appearance.

General

  • Uncommon - seen 3.5% of consecutive 2328 upper endoscopies.[1]
  • Benign.[2]
  • May be associated with GERD;[1] however, lesions do not resolve with PPI treatment.[2]
  • Possible association with ingestion of hot liquids.[3]

Gross/endoscopic

  • Distinctive endoscopic appearance - grey/white raised lesion.[3]

Image

Microscopic

Features:[3]

  • Squamous epithelium with:
    • Superficial clearing of the cytoplasm.
    • Thickening.

Images

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See also

References

  1. 1.0 1.1 Vadva, MD.; Triadafilopoulos, G. (Jul 1993). "Glycogenic acanthosis of the esophagus and gastroesophageal reflux.". J Clin Gastroenterol 17 (1): 79-83. PMID 8409304.
  2. 2.0 2.1 2.2 Tsai, SJ.; Lin, CC.; Chang, CW.; Hung, CY.; Shieh, TY.; Wang, HY.; Shih, SC.; Chen, MJ. (Jan 2015). "Benign esophageal lesions: endoscopic and pathologic features.". World J Gastroenterol 21 (4): 1091-8. doi:10.3748/wjg.v21.i4.1091. PMID 25632181.
  3. 3.0 3.1 3.2 Lopes, S.; Figueiredo, P.; Amaro, P.; Freire, P.; Alves, S.; Cipriano, MA.; Gouveia, H.; Sofia, C. et al. (May 2010). "Glycogenic acanthosis of the esophagus: an unusually endoscopic appearance.". Rev Esp Enferm Dig 102 (5): 341-2. PMID 20524767.