Pseudohyperplastic prostatic adenocarcinoma

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Pseudohyperplastic prostatic adenocarcinoma, also pseudohyperplastic adenocarcinoma is an uncommon type of prostate carcinoma that may mimic benign prostate.

General

  • Uncommon <3% of cases in one series.[1]
  • May mimic benign prostate.[1]
  • Can be found with or without conventional prostatic adenocarcinoma (acinar type).

Microscopic

Features:[2][1]

  • Medium to large glands with an atypical morphology - key low power feature:
    • Papillary or pseudopapillary infoldings, luminal undulations, branching or cystic dilatation.
  • Nuclear features of conventional prostate cancer (nucleoli, nuclear enlargement).

DDx:

Images

Notes:

  • Usually associated with conventional (acinar) prostate adenocarcinoma.
  • Pale abundant cytoplasm - similar to normal prostate.

See also

References

  1. 1.0 1.1 1.2 Arista-Nasr J, Martinez-Benitez B, Valdes S, Hernández M, Bornstein-Quevedo L (2003). "Pseudohyperplastic prostatic adenocarcinoma in transurethral resections of the prostate". Pathol. Oncol. Res. 9 (4): 232–5. doi:PAOR.2003.9.4.0232. PMID 14688829.
  2. Zhou, Ming; Magi-Galluzzi, Cristina (2006). Genitourinary Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 77. ISBN 978-0443066771.