Pleomorphic xanthoastrocytoma

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Pleomorphic xanthoastrocytoma, abbreviated PXA, is neuropathology tumour classically associated with seizures.

General

Features:

  • Classically in the temporal lobe in children and young adults.
  • Associated with seizures.
  • Moderately aggressive (WHO Grade II).[1]

Gross

  • Temporal lobe - classic.
  • Usually assoc. with the leptomeninges,[1] i.e. superficial.

Microscopic

Features:[2]

  • Marked nuclear atypia.
  • Eosinophilic granular bodies - very common.[1]
  • Inflammation (chronic).

Notes:

Images

Stains

Image:

IHC

  • GFAP +ve.
  • CD68 +ve.

See also

References

  1. 1.0 1.1 1.2 Fouladi, M.; Jenkins, J.; Burger, P.; Langston, J.; Merchant, T.; Heideman, R.; Thompson, S.; Sanford, A. et al. (Jul 2001). "Pleomorphic xanthoastrocytoma: favorable outcome after complete surgical resection.". Neuro Oncol 3 (3): 184-92. PMID 11465399.
  2. Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1333. ISBN 978-1416031215.
  3. 3.0 3.1 Dias-Santagata, D.; Lam, Q.; Vernovsky, K.; Vena, N.; Lennerz, JK.; Borger, DR.; Batchelor, TT.; Ligon, KL. et al. (2011). "BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications.". PLoS One 6 (3): e17948. doi:10.1371/journal.pone.0017948. PMID 21479234.