Nuclear atypia

Nuclear atypia is abnormal change of the cell nucleus. Nuclear atypia is often seen in malignancy; however, it may be seen in benign conditions - notably inflammation.

Cancer with minimal nuclear atypia

• Low grade papillary urothelial carcinoma.
• Some adenocarcinomas of the upper gastrointestinal tract, e.g. gallbladder adenocarcinoma, stomach adenocarcinoma, ductal adenocarcinoma of the pancreas.
• Invasive lobular carcinoma.

See also

• Nuclear pleomorphism.
• Reactive atypia.