Mucinous breast carcinoma
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Mucinous breast carcinoma is an uncommon form of breast cancer that has a good prognosis compared to the common ductal carcinoma.
It is also known as mucinous carcinoma of the breast, and colloid carcinoma of the breast.
General
- Rare.
- Good prognosis.[1]
- Usually older women.
Gross
- Pale, glistening, jelly-like appearance.
- Well-circumscribed.
Image:
Microscopic
Features:
- Malignant mucin producing glands.
- Mucinous component must comprise >90% of the tumour - required for diagnosis.[2]
- Cells should float in the mucin - key feature.
- Glands typically have irregular edges.
- +/-Vessels within the mucin pools.
DDx:
- DCIS with a mucinous component.
- Mucin has a homogenous appearance, mucin lacks vascularization, mucin pools have a regular border.
Note:
- The amount of mucinous component to call mucinous carcinoma varies by anatomical site.
- All mucinous lesions should be excised.[3]
IHC
- ER +ve.
- PR +ve.
- HER2 -ve.
See also
References
- ↑ Barkley, CR.; Ligibel, JA.; Wong, JS.; Lipsitz, S.; Smith, BL.; Golshan, M. (Oct 2008). "Mucinous breast carcinoma: a large contemporary series.". Am J Surg 196 (4): 549-51. doi:10.1016/j.amjsurg.2008.06.013. PMID 18809061.
- ↑ Dogan, E.; Aksoy, S.; Dizdar, O.; Arslan, C.; Dede, DS.; Ozisik, Y.; Altundag, K.. "Pure mucinous carcinoma of the breast: a single center experience.". J BUON 16 (3): 565-7. PMID 22006768.
- ↑ Jacobs, TW.; Connolly, JL.; Schnitt, SJ. (Sep 2002). "Nonmalignant lesions in breast core needle biopsies: to excise or not to excise?". Am J Surg Pathol 26 (9): 1095-110. PMID 12218567.