Proton pump inhibitor effect

Stomach with PPI effect. H&E stain.

Proton pump inhibitor effect, abbreviated PPI effect, is a change seen in the parietal cells of the stomach due to a drug in the proton pump inhibitor class.

Formally, it is stomach with proton pump inhibitor effect.

General

• Due to intake of a proton pump inhibitor (PPI).
  • Used to treat gastroesophageal reflux disease.

Microscopic

Features:

• Parietal cell enlargement - key feature.
  • Parietal cells typically bulge into the lumen.

Images

• 

  PPI effect - intermed. mag. (WC)

• 

  PPI effect - high mag. (WC)

• 

  PPI effect - very high mag. (WC)

www:

• PPI effect (nature.com).

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• Usually not reported.

See also

• Stomach.