Sex cord tumour with annular tubules
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| Sex cord tumour with annular tubules | |
|---|---|
| Diagnosis in short | |
 SCTAT. H&E stain. | |
|
| |
| LM | well-circumscribed nests of cells with nuclei at the periphery, annular tubules (ring-shaped tubules) with dense hyaline material |
| Subtypes | benign, malignant (very rare) |
| LM DDx | Sertoli-Leydig tumour, granulosa cell tumour, Brenner tumour |
| Site | ovary - see ovarian tumours |
|
| |
| Syndromes | Peutz-Jeghers syndrome |
|
| |
| Prevalence | uncommon |
| Prognosis | usually good (benign) |
| Clin. DDx | ovarian tumour |
Sex cord tumour with annular tubules, abbreviated SCTAT, is an uncommon sex cord tumour.
It is not sex cord tumour with angulated tubules.
General
- Associated with Peutz-Jeghers syndrome.[1]
- Large tumours more likely sporadic.
- Small tumours more likely Peutz-Jeghers syndrome and incidental.
- Usually benign.
- Malignant cases reported.[2]
Microscopic
Features:
- Well-circumscribed nests of cells with nuclei at the periphery.
- Annular tubules (ring-shaped tubules) with dense hyaline material.
Notes:
- Annular = shape of a ring.[3]
- May focally have features of Sertoli cell tumour or granulosa cell tumour.[4]
DDx:
- Sertoli-Leydig tumour - has double palisading with overlap of the layers.
- Granulosa cell tumour - have Call-Exner bodies, which don't have a well-defined/solid content.
- Brenner tumour - coffee-bean nuclei.
Images
www:
SCTAT - intermed. mag. (WC)
SCTAT - high mag. (WC)
SCTAT - very high mag. (WC)
SCTAT - very high mag. (WC)
See also
References
- ↑ Purohit, RC.; Alam, SZ. (Mar 1980). "Sex cord tumour of the ovary with annular tubules (SCTAT).". Histopathology 4 (2): 147-54. PMID 7358344.
- ↑ Lele, SM.; Sawh, RN.; Zaharopoulos, P.; Adesokan, A.; Smith, M.; Linhart, JM.; Arrastia, CD.; Krigman, HR. (Apr 2000). "Malignant ovarian sex cord tumor with annular tubules in a patient with Peutz-Jeghers syndrome: a case report.". Mod Pathol 13 (4): 466-70. doi:10.1038/modpathol.3880079. PMID 10786816.
- ↑ URL: http://dictionary.reference.com/browse/annular. Accessed on: 6 August 2011.
- ↑ Young, RH.; Welch, WR.; Dickersin, GR.; Scully, RE. (Oct 1982). "Ovarian sex cord tumor with annular tubules: review of 74 cases including 27 with Peutz-Jeghers syndrome and four with adenoma malignum of the cervix.". Cancer 50 (7): 1384-402. PMID 7104978.