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Difference between revisions of "Kidney tumours"
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Selected common tumours of the kidney:<ref>{{Ref GUP|281-304}}</ref><ref name=pmid19494850>{{Cite journal | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | title = Uncommon and recently described renal carcinomas. | journal = Mod Pathol | volume = 22 Suppl 2 | issue = | pages = S2-S23 | month = Jun | year = 2009 | doi = 10.1038/modpathol.2009.70 | PMID = 19494850 }}</ref> | Selected common tumours of the kidney:<ref>{{Ref GUP|281-304}}</ref><ref name=pmid19494850>{{Cite journal | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | title = Uncommon and recently described renal carcinomas. | journal = Mod Pathol | volume = 22 Suppl 2 | issue = | pages = S2-S23 | month = Jun | year = 2009 | doi = 10.1038/modpathol.2009.70 | PMID = 19494850 }}</ref> | ||
{| class="wikitable" | {| class="wikitable" | ||
| | | | ||
|'''Clear cell RCC''' | |'''Clear cell RCC''' | ||
|'''Papillary RCC<br>type 1''' | |'''Papillary RCC<br>type 1''' | ||
|'''Papillary RCC<br>type 2''' | |'''Papillary RCC<br>type 2''' | ||
| | |'''Chromophobe RCC<br>classic variant''' | ||
| '''Chromophobe RCC<br>eosinophilic variant''' | |||
| '''Oncocytoma''' | |||
| | |||
| | |||
|- | |- | ||
| | |Gross | ||
| | | Golden yellow, solid | ||
| | | friable | ||
| | | friable | ||
| | | light brown | ||
| | | light brown | ||
| | | mahogany/brown, +/-central scar | ||
|- | |- | ||
| | |Architecture | ||
| | | nests, sheets | ||
| papillary, simple | |||
| papillary,<br>pseudostratified | |||
| nests, sheets | |||
| nests, sheets | |||
| nests, sheets | | nests, sheets | ||
|- | |- | ||
| | |Nuclear atypia | ||
| | | low-high<br>typically medium-high | ||
| | | low-medium | ||
| medium-high | |||
| low-high | |||
| low-high | |||
| low-medium, round nuclei | | low-medium, round nuclei | ||
| eosinophilic/<br>granular & <br> | |- | ||
|Cytoplasm | |||
| clear | |||
| eosinophilic | |||
| eosinophilic | |||
| cobwebs/clear | |||
| eosinophilic/cobwebs | |||
| eosinophilic/<br>granular & abundant | |||
|- | |||
|Other | |||
| delicate vessels,<br>necrosis common | |||
| histiocytes<br> in fibrovascular cores, >0.5 cm | |||
| histiocytes<br> in fibrovascular cores, >0.5 cm | |||
| perinuclear clearing, thick vessels | |||
| perinuclear clearing, thick vessels | |||
| in loose fibrous/hyaline stroma | | in loose fibrous/hyaline stroma | ||
|- | |- | ||
|IHC | |||
|CK7-, EMA+ | |||
|AMACR+, EMA+, CK7+ | |||
|AMACR+, E-cadherin+, CK7- | |||
|CD117+, CK7+ (membrane) | |||
|CD117+, CK7+ (membrane) | |||
|Vimentin-, EMA+ | |||
|- | |||
|Main DDx | |||
|chromophobe<br>classic variant | |||
|PaRCC type 2, mets | |||
|PaRCC type 1, mets | |||
|clear cell RCC | |||
|oncocytoma | |||
|chromophobe<br>eosinophilic variant | |||
|- | |||
|Key features ||clear cells, vascular || papillae, histiocytes<br>simple epithelium ||papillae, histiocytes,<br>stratified ||perinuc. clearing,<br>wispy cytoplasm ||perinuc. clearing,<br>wispy eosinophilic<br>cytoplasm ||eosinophilic, granular cytoplasm | |||
|} | |} | ||
Notes: | Notes: | ||