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Difference between revisions of "Molecular pathology"
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m
→Cytogenetics: tweak
m (→Cytogenetics: tweak) |
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| Interphase ISH break apart probe (two colours) | | Interphase ISH break apart probe (two colours) | ||
| probes label two parts of a (normal) gene; the two markers straddle (common) break points | | probes label two parts of a (normal) gene; the two markers straddle (common) break points | ||
| gene fragmentation consistent with translocation; one may find: | | gene fragmentation consistent with translocation; one may find: gene duplication (or chromosomal duplication), gene loss (or chromosome loss) | ||
| $$$ | | $$$ | ||
| can detect translocations - without knowing the specific fusion product | | can detect translocations - without knowing the specific fusion product | ||
| Line 90: | Line 90: | ||
| Interphase ISH fusion probe (two colours) | | Interphase ISH fusion probe (two colours) | ||
| probes label different genes (that are not adjacent) | | probes label different genes (that are not adjacent) | ||
| translocation involving the two genes labeled; one may find: gene duplication, loss | | translocation involving the two genes labeled; one may find: gene duplication (or chromosomal duplication), gene loss (or chromosome loss) | ||
| $$$ | | $$$ | ||
| can detect one specific translocation | | can detect one specific translocation | ||
| Line 96: | Line 96: | ||
| Interphase ISH probe (one colour) | | Interphase ISH probe (one colour) | ||
| probe labels one region (gene) | | probe labels one region (gene) | ||
| gene duplication, loss | | gene duplication (or chromosomal duplication), gene loss (or chromosome loss) | ||
| $$ | | $$ | ||
| | | | ||