Difference between revisions of "Sertoli cell tumour"

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| LMDDx      =  [[granulosa cell tumour]], epithelioid [[adenomatoid tumour]], [[sertoli cell nodule]], [[Sertoli-Leydig tumour]]
| LMDDx      =  [[granulosa cell tumour]], epithelioid [[adenomatoid tumour]], [[sertoli cell nodule]], [[Sertoli-Leydig tumour]]
| Stains    =
| Stains    =
| IHC        = alpha-inhibin, calretinin
| IHC        = [[SF-1]] +ve, alpha-inhibin +ve, calretinin +ve/-ve,
| EM        =
| EM        =
| Molecular  =
| Molecular  =
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==IHC==
==IHC==
*Alpha-inhibin +ve (~95% of cases<ref name=pmid17721194/>).
*Alpha-inhibin +ve (~95% of cases<ref name=pmid17721194/>).
*Calretiin +ve (~55% of cases<ref name=pmid17721194/>).
*[[Calretinin]] +ve (~55% of cases<ref name=pmid17721194/>).
*Beta-catenin +ve (nuclear).<ref>{{cite journal |authors=Zhang C, Ulbright TM |title=Nuclear Localization of β-Catenin in Sertoli Cell Tumors and Other Sex Cord-Stromal Tumors of the Testis: An Immunohistochemical Study of 87 Cases |journal=Am J Surg Pathol |volume=39 |issue=10 |pages=1390–4 |date=October 2015 |pmid=26034868 |doi=10.1097/PAS.0000000000000455 |url=}}</ref>
*Beta-catenin +ve (nuclear).<ref>{{cite journal |authors=Zhang C, Ulbright TM |title=Nuclear Localization of β-Catenin in Sertoli Cell Tumors and Other Sex Cord-Stromal Tumors of the Testis: An Immunohistochemical Study of 87 Cases |journal=Am J Surg Pathol |volume=39 |issue=10 |pages=1390–4 |date=October 2015 |pmid=26034868 |doi=10.1097/PAS.0000000000000455 |url=}}</ref>
**Negative beta-catenin should make one consider other diagnoses.{{fact}}
**Negative beta-catenin should make one consider other diagnoses.{{fact}}
**May be negative in malignant sertoli cell tumours.
**May be negative in malignant sertoli cell tumours.
*[[SF-1]] +ve.<ref name=pmid23165333>{{cite journal |authors=Sangoi AR, McKenney JK, Brooks JD, Higgins JP |title=Evaluation of SF-1 expression in testicular germ cell tumors: a tissue microarray study of 127 cases |journal=Appl Immunohistochem Mol Morphol |volume=21 |issue=4 |pages=318–21 |date=July 2013 |pmid=23165333 |doi=10.1097/PAI.0b013e318277cf5a |url=}}</ref>
**Germ cell tumours -ve.


Others:
Others:
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*[[Leydig cell tumour]].
*[[Leydig cell tumour]].
*[[Sertoli-Leydig tumour]].
*[[Sertoli-Leydig tumour]].
*[[Sex cord-stromal tumours]]
*[[Testis]].
*[[Testis]].


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