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Difference between revisions of "Ependymoma"
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Update molecular classes.
Jensflorian (talk | contribs) (→General: Update) |
Jensflorian (talk | contribs) (Update molecular classes.) |
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There are currently | There are currently ten main ependymal tumors:<ref name=Ref_WHOCNS_74>{{Ref WHOCNS|74}}</ref> | ||
#Supratentorial [[Subependymoma]] | |||
#Supratentorial ependymoma, ZFTA-fusion positive | #Supratentorial ependymoma, ZFTA-fusion positive | ||
#Supratentorial ependymoma, YAP1-fusion positive | #Supratentorial ependymoma, YAP1-fusion positive | ||
#Posterior fossa [[Subependymoma]] | |||
#Posterior fossa ependymoma group A | #Posterior fossa ependymoma group A | ||
#Posterior fossa ependymoma group B | #Posterior fossa ependymoma group B | ||
#Spinal [[Subependymoma]] | |||
#Spinal ependymoma | #Spinal ependymoma | ||
#Spinal ependymoma, MYCN-amplified | #Spinal ependymoma, MYCN-amplified | ||
#[[Myxopapillary ependymoma]] | #[[Myxopapillary ependymoma]] | ||
Ependymoma, NOS (not otherwise specified): Molecular analysis still missing. | Ependymoma, NOS (not otherwise specified): Molecular analysis still missing. | ||
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**Cellular ependymoma. | **Cellular ependymoma. | ||
**Ependymoma, RELA fusion-positive.<ref>{{Cite journal | last1 = Parker | first1 = M. | last2 = Mohankumar | first2 = KM. | last3 = Punchihewa | first3 = C. | last4 = Weinlich | first4 = R. | last5 = Dalton | first5 = JD. | last6 = Li | first6 = Y. | last7 = Lee | first7 = R. | last8 = Tatevossian | first8 = RG. | last9 = Phoenix | first9 = TN. | title = C11orf95-RELA fusions drive oncogenic NF-κB signalling in ependymoma. | journal = Nature | volume = 506 | issue = 7489 | pages = 451-5 | month = Feb | year = 2014 | doi = 10.1038/nature13109 | PMID = 24553141 }}</ref><ref>{{Cite journal | last1 = Pietsch | first1 = T. | last2 = Wohlers | first2 = I. | last3 = Goschzik | first3 = T. | last4 = Dreschmann | first4 = V. | last5 = Denkhaus | first5 = D. | last6 = Dörner | first6 = E. | last7 = Rahmann | first7 = S. | last8 = Klein-Hitpass | first8 = L. | title = Supratentorial ependymomas of childhood carry C11orf95-RELA fusions leading to pathological activation of the NF-κB signaling pathway. | journal = Acta Neuropathol | volume = 127 | issue = 4 | pages = 609-11 | month = Apr | year = 2014 | doi = 10.1007/s00401-014-1264-4 | PMID = 24562983 }}</ref> This is now called Supratentorial ependymoma, ZFTA-fusion positive. | **Ependymoma, RELA fusion-positive.<ref>{{Cite journal | last1 = Parker | first1 = M. | last2 = Mohankumar | first2 = KM. | last3 = Punchihewa | first3 = C. | last4 = Weinlich | first4 = R. | last5 = Dalton | first5 = JD. | last6 = Li | first6 = Y. | last7 = Lee | first7 = R. | last8 = Tatevossian | first8 = RG. | last9 = Phoenix | first9 = TN. | title = C11orf95-RELA fusions drive oncogenic NF-κB signalling in ependymoma. | journal = Nature | volume = 506 | issue = 7489 | pages = 451-5 | month = Feb | year = 2014 | doi = 10.1038/nature13109 | PMID = 24553141 }}</ref><ref>{{Cite journal | last1 = Pietsch | first1 = T. | last2 = Wohlers | first2 = I. | last3 = Goschzik | first3 = T. | last4 = Dreschmann | first4 = V. | last5 = Denkhaus | first5 = D. | last6 = Dörner | first6 = E. | last7 = Rahmann | first7 = S. | last8 = Klein-Hitpass | first8 = L. | title = Supratentorial ependymomas of childhood carry C11orf95-RELA fusions leading to pathological activation of the NF-κB signaling pathway. | journal = Acta Neuropathol | volume = 127 | issue = 4 | pages = 609-11 | month = Apr | year = 2014 | doi = 10.1007/s00401-014-1264-4 | PMID = 24562983 }}</ref> This is now called Supratentorial ependymoma, ZFTA-fusion positive. | ||
**Anaplastic ependymoma. | **Anaplastic ependymoma. This is now called CNS grade 3 ependymoma. | ||
==Gross== | ==Gross== | ||