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==General== | ==General== | ||
*Common abdominal [[pediatric pathology|pediatric]] tumour. | *Common abdominal [[pediatric pathology|pediatric]] tumour. | ||
**Affects approximately 1 in 8000 children. | |||
**There is no sex predilection and the mean patient age at diagnosis ranges among 37 to 43 months. | |||
*May be associated with a syndrome:<ref>URL: [http://emedicine.medscape.com/article/989398-overview http://emedicine.medscape.com/article/989398-overview]. Accessed on: 9 March 2011.</ref> | *May be associated with a syndrome:<ref>URL: [http://emedicine.medscape.com/article/989398-overview http://emedicine.medscape.com/article/989398-overview]. Accessed on: 9 March 2011.</ref> | ||
**WAGR syndrome (Wilms tumour, Aniridia (absence of iris), GU abnormalities, Retardation).<ref>{{OMIM|194072}}</ref> | **WAGR syndrome (Wilms tumour, Aniridia (absence of iris), GU abnormalities, Retardation).<ref>{{OMIM|194072}}</ref> | ||
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==Gross== | ==Gross== | ||
* | Features <ref name="pmid10193955">{{Cite journal | last1 = Coppes | first1 = MJ. | last2 = Arnold | first2 = M. | last3 = Beckwith | first3 = JB. | last4 = Ritchey | first4 = ML. | last5 = D'Angio | first5 = GJ. | last6 = Green | first6 = DM. | last7 = Breslow | first7 = NE. | title = Factors affecting the risk of contralateral Wilms tumor development: a report from the National Wilms Tumor Study Group. | journal = Cancer | volume = 85 | issue = 7 | pages = 1616-25 | month = Apr | year = 1999 | doi = | PMID = 10193955 }}</ref> | ||
*Most nephroblastomas are unifocal. | |||
**Usually solitary, rounded, multilobular masses sharply demarcated from adjacent parenchyma. | |||
**The cut surface is most commonly pale grey or tan. | |||
**Cyst most be prominent in some cases. | |||
*Multifocal masses in a single kidney and bilateral primary lesions are less frequent. | |||
===Images=== | ===Images=== | ||
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Features - classically three components (blastema, immature stroma, tubules):<ref name=Ref_PCPBoD8_254-5>{{Ref PCPBoD8|254-5}}</ref> | Features - classically three components (blastema, immature stroma, tubules):<ref name=Ref_PCPBoD8_254-5>{{Ref PCPBoD8|254-5}}</ref> | ||
#Malignant [[Small round blue cell tumours|small round blue cells]] ("blastema"): | #Malignant [[Small round blue cell tumours|small round blue cells]] ("blastema"): | ||
#*The blastemal component is the least differentiated cellular element. | |||
#*Size = ~ 2x RBC diameter. | #*Size = ~ 2x RBC diameter. | ||
#*Nuclear pleomorphism (variation of size, shape and staining). | #*Nuclear pleomorphism (variation of size, shape and staining). |
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