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Difference between revisions of "Hyalinizing trabecular tumour"
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Hyalinizing trabecular tumour (view source)
Revision as of 02:00, 19 March 2019
, 02:00, 19 March 2019no edit summary
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*Trabecular arrangement of cells. | *Trabecular arrangement of cells. | ||
**May have "curved" trabeculae. | **May have "curved" trabeculae. | ||
**Well defined cell borders. | |||
*Extracellular space has hyaline material - '''key feature'''. | *Extracellular space has hyaline material - '''key feature'''. | ||
*Cytoplasm mimics hyaline material in the extracellular space. | *Cytoplasm mimics hyaline material in the extracellular space. | ||
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*Thyroglobulin +ve. | *Thyroglobulin +ve. | ||
*NSE +ve. | *NSE +ve. | ||
*[[Ki-67 membranous pattern]].<ref name=pmid17525638>{{Cite journal | last1 = Leonardo | first1 = E. | last2 = Volante | first2 = M. | last3 = Barbareschi | first3 = M. | last4 = Cavazza | first4 = A. | last5 = Dei Tos | first5 = AP. | last6 = Bussolati | first6 = G. | last7 = Papotti | first7 = M. | title = Cell membrane reactivity of MIB-1 antibody to Ki67 in human tumors: fact or artifact? | journal = Appl Immunohistochem Mol Morphol | volume = 15 | issue = 2 | pages = 220-3 | month = Jun | year = 2007 | doi = 10.1097/01.pai.0000213122.66096.f0 | PMID = 17525638 }}</ref> | *Ki-67 - [[Ki-67 membranous pattern|may have membranous pattern]].<ref name=pmid17525638>{{Cite journal | last1 = Leonardo | first1 = E. | last2 = Volante | first2 = M. | last3 = Barbareschi | first3 = M. | last4 = Cavazza | first4 = A. | last5 = Dei Tos | first5 = AP. | last6 = Bussolati | first6 = G. | last7 = Papotti | first7 = M. | title = Cell membrane reactivity of MIB-1 antibody to Ki67 in human tumors: fact or artifact? | journal = Appl Immunohistochem Mol Morphol | volume = 15 | issue = 2 | pages = 220-3 | month = Jun | year = 2007 | doi = 10.1097/01.pai.0000213122.66096.f0 | PMID = 17525638 }}</ref> | ||
==Molecular== | |||
*GLIS rearrangement (PAX8-GLIS3, PAX8-GLIS1).<ref name=pmid30648929>{{Cite journal | last1 = Nikiforova | first1 = MN. | last2 = Nikitski | first2 = AV. | last3 = Panebianco | first3 = F. | last4 = Kaya | first4 = C. | last5 = Yip | first5 = L. | last6 = Williams | first6 = M. | last7 = Chiosea | first7 = SI. | last8 = Seethala | first8 = RR. | last9 = Roy | first9 = S. | title = GLIS Rearrangement is a Genomic Hallmark of Hyalinizing Trabecular Tumor of the Thyroid Gland. | journal = Thyroid | volume = 29 | issue = 2 | pages = 161-173 | month = Feb | year = 2019 | doi = 10.1089/thy.2018.0791 | PMID = 30648929 }}</ref> | |||
==See also== | ==See also== | ||