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Difference between revisions of "Anastomosing hemangioma of the kidney"
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Anastomosing hemangioma of the kidney (view source)
Revision as of 13:33, 28 December 2018
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Anastomosing hemangioma of the kidney -- intermed mag.jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = Anastomosing hemangioma of the kidney. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = renal anastomosing hemangioma | ||
| Micro = vascular tumour with architecture similar to splenic sinsoids, hobnailing, +/-[[hyaline globules]], +/-[[extramedullary | | Micro = vascular tumour with architecture similar to splenic sinsoids, hobnailing, +/-[[hyaline globules]], +/-[[extramedullary hematopoiesis]] | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[angiosarcoma]], other [[hemangioma]]s, other [[vascular tumours]] | | LMDDx = [[angiosarcoma]], other [[hemangioma]]s, other [[vascular tumours]], [[angiomyolipoma]] | ||
| Stains = | | Stains = | ||
| IHC = CD34 +ve, CD31 +ve, HHV-8 | | IHC = CD34 +ve, CD31 +ve, HHV-8 | ||
| Line 13: | Line 13: | ||
| Molecular = | | Molecular = | ||
| IF = | | IF = | ||
| Gross = brown/mahogany | | Gross = brown/mahogany lesion, classically centered on medulla of kidney | ||
| Grossing = | | Grossing = [[total nephrectomy for tumour grossing]], [[partial nephrectomy grossing]] | ||
| Staging = | | Staging = | ||
| Site = [[kidney]] | | Site = [[kidney]] | ||
| Assdx = +/-[[end stage renal disease]] | | Assdx = +/-[[end stage renal disease]] | ||
| Syndromes = | | Syndromes = | ||
| Line 24: | Line 24: | ||
| Prevalence = very rare | | Prevalence = very rare | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = | | Rads = may mimic [[renal cell carcinoma]] | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = benign | | Prognosis = benign | ||
| Other = | | Other = | ||
| ClinDDx = | | ClinDDx = [[renal tumours]] | ||
| Tx = | | Tx = excision for definitive diagnosis? | ||
}} | }} | ||
'''Anastomosing hemangioma''' a rare benign [[vascular tumour]] | '''Anastomosing hemangioma of the kidney''' a rare benign [[vascular tumour]] of [[kidney]] that may mimic [[angiosarcoma]].<ref name=pmid19606014>{{Cite journal | last1 = Montgomery | first1 = E. | last2 = Epstein | first2 = JI. | title = Anastomosing hemangioma of the genitourinary tract: a lesion mimicking angiosarcoma. | journal = Am J Surg Pathol | volume = 33 | issue = 9 | pages = 1364-9 | month = Sep | year = 2009 | doi = 10.1097/PAS.0b013e3181ad30a7 | PMID = 19606014 }}</ref> | ||
==General== | ==General== | ||
*Rare - case reports. | *Rare - case reports. | ||
**The bigger category ''vascular tumours of the kidney'' is rare; in the world literature (as of 2015), according to Omiyale, there are approximately 40 angiosarcoma and 220 hemangiomas.<ref name=pmid26244138>{{Cite journal | last1 = Omiyale | first1 = AO. | title = Anastomosing hemangioma of the kidney: a literature review of a rare morphological variant of hemangioma. | journal = Ann Transl Med | volume = 3 | issue = 11 | pages = 151 | month = Jul | year = 2015 | doi = 10.3978/j.issn.2305-5839.2015.06.16 | PMID = 26244138 }}</ref> | |||
*Typically seen in [[end stage renal disease]].<ref name=pmid27543862/> | *Typically seen in [[end stage renal disease]].<ref name=pmid27543862/> | ||
*May mimic renal cell carcinoma clinically.<ref name=pmid28727378>{{Cite journal | last1 = Silva | first1 = MA. | last2 = Fonseca | first2 = EKUN. | last3 = Yamauchi | first3 = FI. | last4 = Baroni | first4 = RH. | title = Anastomosing hemangioma simulating renal cell carcinoma. | journal = Int Braz J Urol | volume = 43 | issue = 5 | pages = 987-989 | month = | year = | doi = 10.1590/S1677-5538.IBJU.2016.0653 | PMID = 28727378 }}</ref> | |||
==Gross== | ==Gross== | ||
Features: | Features: | ||
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==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
*Vascular tumour characterized by vessels that fuse/join (anastomose) | *Vascular tumour characterized by vessels that fuse/join (anastomose); described as ''splenic sinusoids-like''.<ref name=pmid27543862/> | ||
**+/-[[Hobnail morphology]]. | **+/-[[Hobnail morphology]]. | ||
**+/-Cytoplasmic hyaline globules. | **+/-Cytoplasmic hyaline globules. | ||
*+/-Extramedullary hematopoiesis. | *+/-[[Extramedullary hematopoiesis]]. | ||
**Nucleated red blood | **[[Nucleated red blood cell]]s. | ||
**Megakaryocytes. | **Megakaryocytes. | ||
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DDx: | DDx: | ||
*[[Angiosarcoma]] - [[nuclear atypia]], more proliferative activity. | *[[Angiosarcoma]] - [[nuclear atypia]], more proliferative activity. | ||
*[[Angiomyolipoma]]. | |||
===Images=== | |||
<gallery> | |||
Image: Anastomosing hemangioma of the kidney -- low mag.jpg | AH - low mag. (WC) | |||
Image: Anastomosing hemangioma of the kidney -- intermed mag.jpg | AH - intermed. mag. (WC) | |||
Image: Anastomosing hemangioma of the kidney -- high mag.jpg | AH - high mag. (WC) | |||
Image: Anastomosing hemangioma of the kidney -- very high mag.jpg | AH - very high mag. (WC) | |||
Image: Anastomosing hemangioma of the kidney - alt -- extremely low mag.jpg | AH - extremely low mag. (WC) | |||
Image: Anastomosing hemangioma of the kidney - alt -- very low mag.jpg | AH - very low mag. (WC) | |||
Image: Anastomosing hemangioma of the kidney - alt -- low mag.jpg | AH - low mag. (WC) | |||
Image: Anastomosing hemangioma of the kidney - alt -- intermed mag.jpg | AH - intermed. mag. (WC) | |||
Image: Anastomosing hemangioma of the kidney - b -- intermed mag.jpg | AH - intermed. mag. (WC) | |||
Image: Anastomosing hemangioma of the kidney - b -- high mag.jpg | AH - high mag. (WC) | |||
</gallery> | |||
==IHC== | ==IHC== | ||
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[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Soft tissue lesions]] | [[Category:Soft tissue lesions]] | ||
[[Category:Kidney tumours]] | |||