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→Molecular: IDh1/2 sequencing
Jensflorian (talk | contribs) (→IHC: secondary GBM) |
Jensflorian (talk | contribs) (→Molecular: IDh1/2 sequencing) |
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==Molecular== | ==Molecular== | ||
*IDH1/2 sequencing in cases below 55 years is mandatory to separate between Glioblastoma, IDH-wildtype and Glioblastoma IDH-mutant. | |||
** In cases above 55 years, negative IDH1 R132H immunohistochemistry may be sufficient. | |||
*Seen in inherited tumor syndromes: | *Seen in inherited tumor syndromes: | ||
**Lynch-Syndrome | **Lynch-Syndrome | ||