Difference between revisions of "Programmed death-ligand 1"

Programmed death-ligand 1 (view source)

36 bytes added , 02:48, 12 May 2016

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 ===Background===
-Cytotoxic T cell activation is driven by two sets of receptors:<ref name=pmid22658126>{{Cite journal  | last1 = Ribas | first1 = A. | title = Tumor immunotherapy directed at PD-1. | journal = N Engl J Med | volume = 366 | issue = 26 | pages = 2517-9 | month = Jun | year = 2012 | doi = 10.1056/NEJMe1205943 | PMID = 22658126 }}</ref>
+Cytotoxic T cell function is regulated by receptor pairs found on the tumour and lymphocyte:<ref name=pmid22658126>{{Cite journal  | last1 = Ribas | first1 = A. | title = Tumor immunotherapy directed at PD-1. | journal = N Engl J Med | volume = 366 | issue = 26 | pages = 2517-9 | month = Jun | year = 2012 | doi = 10.1056/NEJMe1205943 | PMID = 22658126 }}</ref>
 {| class="wikitable sortable"
 ! Function
@@ Line 19: / Line 19: @@
 | TCR
 |-
-| Inhibition
+| Signal inhibition
-| [[PD-1]]
+| PD-1
-| PD-L1 (CD274), PD-L2 (CD273)
+| [[PD-L1]] (CD274), PD-L2 (CD273)
 |}