48,860
edits
Difference between revisions of "Spindle cell lipoma"
Jump to navigation
Jump to search
split out
(+cat.) |
(split out) |
||
| Line 1: | Line 1: | ||
'''Spindle cell lipoma''' is a rare benign [[adipocytic tumours|adipocytic tumour]]. | |||
==General== | |||
*Rare. | |||
*Predominantly men.<ref name=pmid15371618/> | |||
Note: | |||
*Spindle cell lipoma may immunohistochemically and histomorphologically overlap with ''mammary-type myofibroblastoma''<ref name=pmid11474286>{{Cite journal | last1 = McMenamin | first1 = ME. | last2 = Fletcher | first2 = CD. | title = Mammary-type myofibroblastoma of soft tissue: a tumor closely related to spindle cell lipoma. | journal = Am J Surg Pathol | volume = 25 | issue = 8 | pages = 1022-9 | month = Aug | year = 2001 | doi = | PMID = 11474286 }}</ref> - see: ''[[mammary myofibroblastoma]]''. | |||
==Microscopic== | |||
Features:<ref name=pmid15371618>{{Cite journal | last1 = Murphey | first1 = MD. | last2 = Carroll | first2 = JF. | last3 = Flemming | first3 = DJ. | last4 = Pope | first4 = TL. | last5 = Gannon | first5 = FH. | last6 = Kransdorf | first6 = MJ. | title = From the archives of the AFIP: benign musculoskeletal lipomatous lesions. | journal = Radiographics | volume = 24 | issue = 5 | pages = 1433-66 | month = | year = | doi = 10.1148/rg.245045120 | PMID = 15371618 }}</ref> | |||
*Aligned bland spindled cells adjacent to fat. | |||
*Rope-like collagen bundles - '''key feature'''. | |||
**May be described as "shreaded wheat". | |||
*+/-[[Myxoid]] component. | |||
*+/-[[staghorn vessels|Staghorn-like vessels]]. | |||
Notes: | |||
*May overlap with ''[[pleomorphic lipoma]]''.<ref name=spc_stanford>URL: [http://surgpathcriteria.stanford.edu/softfat/spindle_cell_lipoma/ http://surgpathcriteria.stanford.edu/softfat/spindle_cell_lipoma/]. Accessed on: 4 December 2010.</ref> | |||
DDx: | |||
*[[Neurofibroma]]. | |||
*Spindle cell [[liposarcoma]] - extremely rare.<ref name=pmid8067512>{{Cite journal | last1 = Dei Tos | first1 = AP. | last2 = Mentzel | first2 = T. | last3 = Newman | first3 = PL. | last4 = Fletcher | first4 = CD. | title = Spindle cell liposarcoma, a hitherto unrecognized variant of liposarcoma. Analysis of six cases. | journal = Am J Surg Pathol | volume = 18 | issue = 9 | pages = 913-21 | month = Sep | year = 1994 | doi = | PMID = 8067512 }}</ref> | |||
===Image=== | |||
www: | |||
*[http://www.webpathology.com/image.asp?n=3&Case=434 Spindle cell lipoma (webpathology.com)]. | |||
==IHC== | |||
*CD34 +ve.<ref name=pmid20559119>{{Cite journal | last1 = Wood | first1 = L. | last2 = Fountaine | first2 = TJ. | last3 = Rosamilia | first3 = L. | last4 = Helm | first4 = KF. | last5 = Clarke | first5 = LE. | title = Cutaneous CD34+ spindle cell neoplasms: Histopathologic features distinguish spindle cell lipoma, solitary fibrous tumor, and dermatofibrosarcoma protuberans. | journal = Am J Dermatopathol | volume = 32 | issue = 8 | pages = 764-8 | month = Dec | year = 2010 | doi = 10.1097/DAD.0b013e3181d0c587 | PMID = 20559119 }}</ref> | |||
*Desmin +ve. | |||
*S100 -ve. (???) | |||
Lipoma versus liposarcoma: | |||
*MDM2 -ve.<ref name=pmid23529275>{{Cite journal | last1 = Alshenawy | first1 = H. | title = Can HMGI-C be used as an aid with MDM2 and CDK4 to differentiate liposarcoma subtypes from their mimics? | journal = J Cancer Res Clin Oncol | volume = 139 | issue = 6 | pages = 1073-81 | month = Jun | year = 2013 | doi = 10.1007/s00432-013-1420-6 | PMID = 23529275 }}</ref> | |||
*p16 -ve.<ref name=pmid24659226>{{Cite journal | last1 = Creytens | first1 = D. | last2 = van Gorp | first2 = J. | last3 = Savola | first3 = S. | last4 = Ferdinande | first4 = L. | last5 = Mentzel | first5 = T. | last6 = Libbrecht | first6 = L. | title = Atypical spindle cell lipoma: a clinicopathologic, immunohistochemical, and molecular study emphasizing its relationship to classical spindle cell lipoma. | journal = Virchows Arch | volume = 465 | issue = 1 | pages = 97-108 | month = Jul | year = 2014 | doi = 10.1007/s00428-014-1568-8 | PMID = 24659226 }}</ref> | |||
==Molecular== | |||
*Retinoblastoma (Rb) deletions.<ref name=pmid24659226>{{Cite journal | last1 = Creytens | first1 = D. | last2 = van Gorp | first2 = J. | last3 = Savola | first3 = S. | last4 = Ferdinande | first4 = L. | last5 = Mentzel | first5 = T. | last6 = Libbrecht | first6 = L. | title = Atypical spindle cell lipoma: a clinicopathologic, immunohistochemical, and molecular study emphasizing its relationship to classical spindle cell lipoma. | journal = Virchows Arch | volume = 465 | issue = 1 | pages = 97-108 | month = Jul | year = 2014 | doi = 10.1007/s00428-014-1568-8 | PMID = 24659226 }}</ref> | |||
*CDK4 no amplication ([[FISH]]).<ref name=pmid24659226/> | |||
==See also== | |||
*[[Mammary myofibroblastoma]]. | |||
*[[Pleomorphic lipoma]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Adipocytic tumours]] | |||