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Difference between revisions of "Biphenotypic sinonasal sarcoma"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
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| Synonyms = low-grade sinonasal sarcoma with neural and myogenic features | |||
| Micro = bland hypercellular stroma typically without many mitoses, invaginating glandular epithelium | |||
| Subtypes = | |||
| LMDDx = [[solitary fibrous tumour]], [[schwannoma]], [[sinonasal-type hemangiopericytoma]], benign [[nasal polyp]] | |||
| Stains = | |||
| IHC = S-100 +ve, actin +ve, beta-catenin +ve (nuclear) | |||
| EM = | |||
| Molecular = PAX3-MAML3 fusion - t(2;4)(q35;q31.1) | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Staging = | |||
| Site = [[head and neck pathology|head and neck]] - ethmoid sinus and/or nasal cavity | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = female predominant (3:1) | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = very rare ~ large series 28 individual as of 2012 | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Biphenotypic sinonasal sarcoma''', abbreviated '''SNS''',<ref name=pmid24859338/> is a rare bland appearing [[cancer|malignant]] tumour of the [[head and neck pathology|head and neck]]. | '''Biphenotypic sinonasal sarcoma''', abbreviated '''SNS''',<ref name=pmid24859338/> is a rare bland appearing [[cancer|malignant]] tumour of the [[head and neck pathology|head and neck]]. | ||
It is also known as '''low grade sinonasal sarcoma with neural and myogenic features'''.<ref>{{Cite journal | last1 = Powers | first1 = KA. | last2 = Han | first2 = LM. | last3 = Chiu | first3 = AG. | last4 = Aly | first4 = FZ. | title = Low-grade sinonasal sarcoma with neural and myogenic features--diagnostic challenge and pathogenic insight. | journal = Oral Surg Oral Med Oral Pathol Oral Radiol | volume = 119 | issue = 5 | pages = e265-9 | month = May | year = 2015 | doi = 10.1016/j.oooo.2014.10.007 | PMID = 25488011 }}</ref> | It is also known as '''low-grade sinonasal sarcoma with neural and myogenic features'''.<ref name=pmid25488011>{{Cite journal | last1 = Powers | first1 = KA. | last2 = Han | first2 = LM. | last3 = Chiu | first3 = AG. | last4 = Aly | first4 = FZ. | title = Low-grade sinonasal sarcoma with neural and myogenic features--diagnostic challenge and pathogenic insight. | journal = Oral Surg Oral Med Oral Pathol Oral Radiol | volume = 119 | issue = 5 | pages = e265-9 | month = May | year = 2015 | doi = 10.1016/j.oooo.2014.10.007 | PMID = 25488011 }}</ref> | ||
==General== | ==General== | ||